FD1024
FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice.
For research use only. We do not sell to patients.
- CAS No.: 1422456-47-0
- Formula: C21H20F2N4O2S
- Molecular Weight:430.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
1.96, 38.9, 4.17 nM for PIM1, 2, 3[1]
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| EOL1 | IC50 |
0.16 μM
Compound: 24
|
Antiproliferative activity against human EOL1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human EOL1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
|
[PMID: 37262997] |
| KG-1 | IC50 |
1.05 μM
Compound: 24
|
Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
|
[PMID: 37262997] |
| MOLM-16 | IC50 |
1.39 μM
Compound: 24
|
Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MOLM16 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
|
[PMID: 37262997] |
| MV4-11 | IC50 |
0.12 μM
Compound: 24
|
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay
|
[PMID: 37262997] |
Chemical Information
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CAS No. 1422456-47-0
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Molecular Weight 430.47
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Formula C21H20F2N4O2S
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SMILES
O=C(C1=CSC(C2=C(F)C=CC=C2F)=N1)NC3=C(O[C@H]4CC[C@H](N)CC4)C=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)