L-Fd4A
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 210474-65-0
- Formula: C10H10FN5O2
- Molecular Weight:251.22
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
>100 μM
Compound: 36
|
Inhibitory activity was evaluated on mitochondrial DNA content of CEM cells
Inhibitory activity was evaluated on mitochondrial DNA content of CEM cells
|
[PMID: 10197975] |
| PBMC | IC50 |
>100 μM
Compound: 36
|
Inhibitory activity was evaluated in human peripheral blood mononuclear (PBM) cells infected with Human immunodeficiency virus-1
Inhibitory activity was evaluated in human peripheral blood mononuclear (PBM) cells infected with Human immunodeficiency virus-1
|
[PMID: 10197975] |
| Vero | IC50 |
>100 μM
Compound: 36
|
Inhibitory activity was evaluated in Vero cells.
Inhibitory activity was evaluated in Vero cells.
|
[PMID: 10197975] |
L-Fd4A (compound 36) has no toxicity in PBM, Vero and CEM cells. L-Fd4A shows any effect on mitochondrial DNA of CEM cells upon long-term exposure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 210474-65-0
-
Molecular Weight 251.22
-
Formula C10H10FN5O2
-
SMILES
OC[C@@H]1O[C@H](N2C3=NC=NC(N)=C3N=C2)C(F)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)