Tralkoxydim
Based on 1 Customer Validation
Tralkoxydim (PP604) is an orally effective herbicide. Tralkoxydim inhibits ACCase (IC50 of 0.5 μM in Lolium rigidum), blocking ATP-dependent acetyl-CoA carboxylation to malonyl-CoA and fatty acid biosynthesis; it activates HRP-catalyzed TMB/PDA peroxidation. Tralkoxydim can be used for research on hepatic porphyria.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 97.22%
- No. CAS: 87820-88-0
- Fòrmula: C20H27NO3
- Peso molecular:329.43
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-B2007
Fluazifop-P-butylACCase Inhibitor -
HY-B0861
Cyhalofop-butylHerbicide Agent -
HY-136380
Clodinafop-propargylHerbicide -
HY-136380R
Clodinafop-propargyl (Standard)Herbicide -
HY-B0861R
Cyhalofop-butyl (Standard)Herbicide Agent -
HY-111223R
Tralkoxydim (Standard)Reference Standard -
HY-B2007R
Fluazifop-P-butyl (Standard)Standard
Actividad biológica
Descripciòn
IC50 & Target
[1]|
ACCase 0.5 μM (IC50) |
In Vitro
Tralkoxydim (3-5 min) inhibits ACCase from both susceptible VLR 1 and resistant VLR 69 L. rigidum with an I50 of 0.5 µM, indicating no altered target-site resistance to tralkoxydim[1].
Tralkoxydim (1 μM; 15 min) inhibits maize (Zea mays L.) shoot ACCase in vitro, producing about 40% inhibition at 1 μM and concentration-dependent inhibition across the 125 nM-75 μM range, with about 25% inhibition at 125 nM and more than 80% inhibition at 75 μM[4].
Tralkoxydim (30 µM; 6 h) was metabolized 77% by resistant L. rigidum VLR 69 versus 41% by susceptible VLR 1, and this enhanced metabolism was not inhibited by PBO, malathion, ABT, or tetcyclacis, supporting a non-target-site resistance mechanism[1].
Tralkoxydim (1.0-5.0 mM) activates HRP-catalyzed TMB and PDA peroxidation in a concentration-dependent manner, increasing HRP activity to 203% for TMB and 212% for PDA at 5.0 mM, with mixed or noncompetitive activation depending on substrate and concentration[2].
Tralkoxydim (0-90 µg/mL) reduces Auxenochlorella sp. Z0 viability with an EC50 of 48.3 µg/mL[3].
Tralkoxydim addition correlates negatively with chlorophyll production in Z0 but positively in E11 and P19, with E11 and P19 showing higher chlorophyll and carotenoid contents under Tralkoxydim[3].
Tralkoxydim (noncytotoxic concentration; Day 7 postseeding) inhibits P-gp activity in MCF7R cells, with IC50 values of 88 μM using Rh123 accumulation and 90 μM using H33342 retention[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tralkoxydim (100 mg/kg; oral gavage; 2 doses separated by 24 h) produces hepatic protoporphyrin accumulation in offspring of wild-caught Mus musculus, comparable to that in CD-1 mice[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD-1 Swiss (commercially supplied; male and female; approximately 2 months old; initial body weights: males 27.57-28.84 g, females 20.92-21.77 g)[8]
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Dosage:100 mg/kg
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Administration:oral gavage in sunflower oil; 2 doses separated by 24 h
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Result:In CD-1 males, mean liver protoporphyrin after tralkoxydim was 84.16 nmol/g (n = 12; pooled Experiments 1 and 2; Experiment 1 mean 94.9 nmol/g; Experiment 2 mean 73.4 nmol/g).
In CD-1 females, mean liver protoporphyrin after tralkoxydim was 44.29 nmol/g (n = 6).
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Animal Model:offspring of wild-caught mice (mixed-sex groups; 2-3 females per group; initial body weight for tralkoxydim high-dose group 22.42 g)[8]
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Dosage:100 mg/kg
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Administration:oral gavage in sunflower oil; 2 doses separated by 24 h
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Result:Mean liver protoporphyrin after high-dose tralkoxydim was 31.17 nmol/g (n = 6; text reports 32.1 nmol/g).
Chemical Information
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No. CAS 87820-88-0
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Appearance Solid
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Peso molecular 329.43
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Fòrmula C20H27NO3
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Color White to off-white
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SMILES
O=C1C(/C(CC)=N\OCC)=C(O)CC(C2=C(C)C=C(C)C=C2C)C1
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Synonyms
PP604; ICIA 0604; FD-4026
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 50 mg/mL (151.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 8.7 mg/mL (26.41 mM; ultrasonic and adjust pH to 11 with 1 M NaOH)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (15.18 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.0355 mL | 15.1777 mL | 30.3555 mL | 75.8887 mL |
| 5 mM | 0.6071 mL | 3.0355 mL | 6.0711 mL | 15.1777 mL | |
| 10 mM | 0.3036 mL | 1.5178 mL | 3.0355 mL | 7.5889 mL | |
| 15 mM | 0.2024 mL | 1.0118 mL | 2.0237 mL | 5.0592 mL | |
| 20 mM | 0.1518 mL | 0.7589 mL | 1.5178 mL | 3.7944 mL | |
| 25 mM | 0.1214 mL | 0.6071 mL | 1.2142 mL | 3.0355 mL | |
| DMSO | 30 mM | 0.1012 mL | 0.5059 mL | 1.0118 mL | 2.5296 mL |
| 40 mM | 0.0759 mL | 0.3794 mL | 0.7589 mL | 1.8972 mL | |
| 50 mM | 0.0607 mL | 0.3036 mL | 0.6071 mL | 1.5178 mL | |
| 60 mM | 0.0506 mL | 0.2530 mL | 0.5059 mL | 1.2648 mL | |
| 80 mM | 0.0379 mL | 0.1897 mL | 0.3794 mL | 0.9486 mL | |
| 100 mM | 0.0304 mL | 0.1518 mL | 0.3036 mL | 0.7589 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tralkoxydim Related Classifications
HY-111223 Related Classifications
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Keywords
- Tralkoxydim
- 87820-88-0
- PP604
- ICIA 0604
- FD-4026
- PP 604
- PP-604
- ICIA0604
- ICIA 0604
- ICIA-0604
- FD4026
- FD 4026
- FD-4026
- Herbicide
- Acetyl-CoA Carboxylase
- ACCase
- Auxenochlorella
- Lolium rigidum
- Mus musculus
- aminolevulinic acid synthetase
- cytochrome P-450
- fatty acid biosynthesis
- ferrochelatase
- hepatic porphyria
- protoporphyrin
- Inhibitor
- inhibitor
- inhibit