Anti-Mouse CD11a Antibody (FD441.8)
Based on 1 Customer Validation
Anti-Mouse CD11a Antibody (FD441.8) is an anti-mouse CD11a IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD11a Antibody (FD441.8) can neutralize CD11a also known as LFA-1α (lymphocyte function-associated antigen 1 alpha). Anti-Mouse CD11a Antibody (FD441.8) can be used for the researches of inflammation, immunology and cancer, such as transplant and leukemia.
For research use only. We do not sell to patients.
- Purity: 95.00%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2b kappa
Mouse
CD11a
Anti-Mouse CD11a Antibody (FD441.8) (300 μg, i.v., at day of hapten-challenge) inhibits CXCL1 production in dinitrofluorobenzene (DNFB) sensitized wild-type mice[2].
Anti-Mouse CD11a Antibody (FD441.8) (T cells pretreated with 50 μg/mL FD441.8 for 30 mins) enhances lung egress and trafficking to the bone marrow in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DNFB sensitized wild-type mice[2]
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Dosage:300 μg
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Administration:Intravenously injection, at day of hapten-challenge
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Result:Inhibited CXCL1 production.
Attenuated or absent neutrophil infiltration.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo LFA-1 neutralization
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD11a Antibody (FD441.8)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (261 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Ashkenazi E, et al. Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy. PLoS One. 2013 May 22;8(5):e63625. [Content Brief]
[2]. Kish DD, et al. Hapten application to the skin induces an inflammatory program directing hapten-primed effector CD8 T cell interaction with hapten-presenting endothelial cells. J Immunol. 2011 Feb 15;186(4):2117-26. [Content Brief]
[3]. James SE, et al. Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. Blood. 2009 Dec 24;114(27):5454-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD11a Antibody (FD441.8) Related Classifications
HY-P99120 Related Classifications
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