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  3. Lalistat 1

Lalistat 1 

Cat. No.: HY-116815
Handling Instructions

Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease.

For research use only. We do not sell to patients.

Lalistat 1 Chemical Structure

Lalistat 1 Chemical Structure

CAS No. : 501104-16-1

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Description

Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease[2].

IC50 & Target

IC50: 68 nM ( human LAL)[1]

In Vitro

Lalistat 1 (0-100 μM) shows activity against different non-typeable H. influenzae (NTHi) IgAP variants from clinical isolates in Elisa assay. It shows a dose-dependent inhibition of IgA1P B1 and B2, but at higher inhibitor concentrations, consistent with the higher expression levels of these variants. Nearly complete inhibition of IgA1P B1 and B2 is observed at 50 μM, with complete inhibition at 100 μM[1].

Molecular Weight

298.36

Formula

C₁₂H₁₈N₄O₃S

CAS No.

501104-16-1

SMILES

O=C(N1CCOCC1)OC2=NSN=C2N3CCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lalistat 1Lalistat1Lalistat-1BacterialHaemophilusinfluenzaeH. influenzaantibiotic resistanceantibacterialresistance,??Niemann-Pick type CNPC diseaseInhibitorinhibitorinhibit

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