1. Metabolic Enzyme/Protease
  2. HCV Protease
  3. BI-1230

BI-1230 

Cat. No.: HY-126973
Handling Instructions

BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity.

For research use only. We do not sell to patients.

BI-1230 Chemical Structure

BI-1230 Chemical Structure

CAS No. : 849022-32-8

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BI-1230 is potent and digit nanomolar inhibitor of HCV NS3 protease and of viral replication. BI-1230 is also highly selective against other serine/cysteine proteases. BI-1230 shows good Pharmacokinetic(PK) activity[1].

IC50 & Target

IC50: 6.7 nM (HCV NS3 protease)[1]

In Vitro

BI-1230 (60 min incubation) exhibits an IC50 value of 6.7 nM in a Enzymatic assay[1].
BI-1230 (72 hours) shows EC50 values of 4.6 nM and <1.8 nM in a Cell-based HCVPV RNA replication Luciferase reporter assay, genotype background 1a and 1b, in Huh7 cells[1].

In Vivo

BI-1230 (intravenous injection; 2 mg/kg) shows good PK activity in rat: CL: 15 ml/min/kg, Mean residence time after iv dose: 2.3 hours, Vss: 2.05 L/kg[1].
BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%[1].

Molecular Weight

816.96

Formula

C₄₂H₅₂N₆O₉S

CAS No.

849022-32-8

SMILES

O=C([[email protected]]([[email protected]]1([H])/C=C\CCCCC[[email protected]@H]2NC(OC3CCCC3)=O)(C1)NC([[email protected]@](C[[email protected]@H](OC4=CC(C5=CSC(NC(C(C)C)=O)=N5)=NC6=C(C)C(OC)=CC=C46)C7)([H])N7C2=O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BI-1230BI1230BI 1230HCV ProteaseHCVproteaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
BI-1230
Cat. No.:
HY-126973
Quantity:
MCE Japan Authorized Agent: