Xeruborbactam disodium  (Synonyms: QPX7728 disodium)

Xeruborbactam (QPX7728) disodium is a potent, ultra-broad-spectrum boronic acid beta-lactamase inhibitor. Xeruborbactam disodium inhibits key serine and metallo beta-lactamases at a nano molar range^[1].

Xeruborbactam disodium is a potent inhibitor of Class D carbapenemases from A. baumannii^[1].
Xeruborbactam disodium is minimally affected by the activity of major MDR efflux pumps from P. aeruginosa, representing a significant improvement over the earlier generation boronate beta-lactamase inhibitor (BLI) vaborbactam^[1].
The ultra-broad-spectrum beta-lactamase inhibition profile combined with enhancement of the activity of multiple beta-lactam antibiotics with varying sensitivity to the intrinsic resistance mechanisms of efflux and permeability indicate Xeruborbactam disodium is a useful inhibitor for use with multiple beta-lactam antibiotics^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

283.96

Solid

C₁₀H₈BFNa₂O₅

2170848-99-2

O[B-](O1)(O)[C@@H]2C[C@@H]2C3=C1C(C(O[Na])=O)=C(C=C3)F.[Na+]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Lomovskaya O, et al, The Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultra-Broad-Spectrum Beta-lactamase Inhibitor of Serine and Metallo Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Antimicrob Agents Chemother. 2020 Mar 30. pii: AAC.00552-20.  [Content Brief]

  [2]. Hecker SJ, Reddy KR, Lomovskaya O, et al. Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases. J Med Chem. 2020;63(14):7491-7507.  [Content Brief]