1. Anti-infection
  2. Bacterial
  3. Cefiderocol

Cefiderocol (Synonyms: S-649266)

Cat. No.: HY-17628 Purity: 98.65%
Handling Instructions

Cefiderocol is a novel siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.

For research use only. We do not sell to patients.

Cefiderocol Chemical Structure

Cefiderocol Chemical Structure

CAS No. : 1225208-94-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 736 In-stock
Estimated Time of Arrival: December 31
5 mg USD 590 In-stock
Estimated Time of Arrival: December 31
10 mg USD 890 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2900 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Cefiderocol is a novel siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.

IC50 & Target

MIC50: <2 μg/mL (Gram-negative bacteria)[1]

In Vitro

Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol has affinity mainly for penicillin-binding protein 3 (PBP3) of Enterobacteriaceae and nonfermenting bacteria similar to that of ceftazidime. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol[1].

Clinical Trial
Storage

-20°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (66.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3294 mL 6.6471 mL 13.2942 mL
5 mM 0.2659 mL 1.3294 mL 2.6588 mL
10 mM 0.1329 mL 0.6647 mL 1.3294 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

For the determination of cefiderocol MIC, iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) is prepared, except for the cases that are required to determine MICs under specific conditions. The quality control MIC ranges of cefiderocol are 0.06 to 0.5 μg/mL for both E. coli ATCC 25922 and P. aeruginosa ATCC 27853. For anaerobic bacteria, brucella agar supplemented with hemin, vitamin K1, and laked sheep blood is used. For recombinant strains, test medium is supplemented with 10 μg/mL of gentamicin and/or 0.1 mM IPTG (isopropyl-β-d-thiogalactopyranoside) when required[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

752.21

Formula

C₃₀H₃₄ClN₇O₁₀S₂

CAS No.

1225208-94-5

SMILES

O=C(C(N12)=C(C[N+]3(CCNC(C4=CC=C(O)C(O)=C4Cl)=O)CCCC3)CS[[email protected]]2([H])[[email protected]](NC(/C(C5=CSC(N)=N5)=N\OC(C)(C(O)=O)C)=O)C1=O)[O-]

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.65%

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Product Name:
Cefiderocol
Cat. No.:
HY-17628
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Cefiderocol

Cat. No.: HY-17628