1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefiderocol

Cefiderocol (Synonyms: S-649266)

Cat. No.: HY-17628 Purity: 98.65%
Handling Instructions

Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.

For research use only. We do not sell to patients.

Cefiderocol Chemical Structure

Cefiderocol Chemical Structure

CAS No. : 1225208-94-5

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5 mg USD 590 In-stock
Estimated Time of Arrival: December 31
10 mg USD 890 In-stock
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25 mg USD 1900 In-stock
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50 mg USD 3500 In-stock
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100 mg USD 6500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50s of 2 μg/mL or less.

IC50 & Target

MIC50: <2 μg/mL (Gram-negative bacteria)[1]

In Vitro

Cefiderocol (S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Cefiderocol has affinity mainly for PBP3 of Enterobacteriaceae and nonfermenting bacteria similar to that of GR20263. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli can cause 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa show no significant impact on the activity of cefiderocol[1].

Clinical Trial
Molecular Weight

752.21

Formula

C₃₀H₃₄ClN₇O₁₀S₂

CAS No.

1225208-94-5

SMILES

O=C(C(N12)=C(C[N+]3(CCNC(C4=CC=C(O)C(O)=C4Cl)=O)CCCC3)CS[[email protected]]2([H])[[email protected]](NC(/C(C5=CSC(N)=N5)=N\OC(C)(C(O)=O)C)=O)C1=O)[O-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (66.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3294 mL 6.6471 mL 13.2942 mL
5 mM 0.2659 mL 1.3294 mL 2.6588 mL
10 mM 0.1329 mL 0.6647 mL 1.3294 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (3.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

For the determination of cefiderocol MIC, iron-depleted cation-adjusted Mueller-Hinton broth (ID-CAMHB) is prepared, except for the cases that are required to determine MICs under specific conditions. The quality control MIC ranges of cefiderocol are 0.06 to 0.5 μg/mL for both E. coli ATCC 25922 and P. aeruginosa ATCC 27853. For anaerobic bacteria, brucella agar supplemented with hemin, vitamin K1, and laked sheep blood is used[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 98.65%

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Keywords:

CefiderocolS-649266S649266S 649266BacterialAntibioticInhibitorinhibitorinhibit

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Cefiderocol
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HY-17628
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