Efficacy of cefiderocol in combination with xeruborbactam versus taniborbactam against cefiderocol-resistant NDM-producing Pseudomonas aeruginosa

  • Antimicrob Agents Chemother. 2025 Nov 5;69(11):e0085725. doi: 10.1128/aac.00857-25.
Kaan Kocer  1  2 ,  Truong Nhat My  3  4 ,  Bui Tien Sy  3  4 ,  Lisa Göpel  1 ,  Thirumalaisamy P Velavan  3  5  6  7 ,  Le Huu Song  3  4  6 ,  Silke Peter  7  8 ,  Sébastien Boutin  1  2  9 ,  Adesola Olalekan  10 ,  Dennis Nurjadi  1  2  3
Affiliations
  • 1. Institute of Medical Microbiology, University of Lübeck and University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany.
  • 2. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany.
  • 3. Vietnamese-German Centre for Medical Research (VG-CARE), Hanoi, Vietnam.
  • 4. 108 Military Central Hospital, Hanoi, Vietnam.
  • 5. Faculty of Medicine, Duy Tan University, Da Nang, Vietnam.
  • 6. Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany.
  • 7. German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany.
  • 8. Institute of Medical Microbiology and Hygiene, Universitätsklinikum Tübingen, Tübingen, Germany.
  • 9. Airway Research Center North (ARCN), German Center for Lung Research (DZL), Lübeck, Germany.
  • 10. Department of Medical Laboratory Science, College of Medicine, University of Lagos, Lagos, Nigeria.
PMID: 41071171 DOI: 10.1128/aac.00857-25
Abstract

We evaluated the in vitro activity of cefiderocol in combination with either taniborbactam or xeruborbactam against cefiderocol-resistant, blaNDM-positive Pseudomonas aeruginosa clinical isolates from Vietnam and Nigeria. Taniborbactam restored cefiderocol susceptibility in most isolates (20/21, 95.2%), while xeruborbactam had no effect. Resistance was reversed by dipicolinic acid, which confirmed New-Delhi Metallo-β-lactamase (NDM-mediated) resistance. One isolate that was unresponsive to taniborbactam carried multiple copies of blaNDM-1. These findings highlight the species-specific limitations of xeruborbactam in P. aeruginosa.

Keywords
NDM; Pseudomonas aeruginosa; cefiderocol; taniborbactam; xeruborbactam.
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