2. Anti-infection
  3. Bacterial
  4. Durlobactam sodium

Durlobactam sodium  (Synonyms: ETX2514)

Cat. No.: HY-117974 Purity: 99.38%
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Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii.

For research use only. We do not sell to patients.

Durlobactam sodium Chemical Structure

Durlobactam sodium Chemical Structure

CAS No. : 1467157-21-6

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5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1650 In-stock
50 mg USD 2650 In-stock
100 mg USD 4280 In-stock
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Based on 1 publication(s) in Google Scholar

Durlobactam sodium Related Antibodies

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Description

Durlobactam sodium salt (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50s of 4, 14 and 190 nM for Class A KPC-2, Class C AmpC and Class D OXA-24, respectively. For the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii[1].

IC50 & Target

IC50: 4 nM (Class A KPC-2), 14 nM (Class C AmpC), 190 nM (Class D OXA-24)[1].
Molecular Weight

299.24

Formula

C8H10N3NaO6S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC([C@H]1[N@@]2C(N([C@H](C=C1C)C2)OS(=O)(O[Na])=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (835.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3418 mL 16.7090 mL 33.4180 mL
5 mM 0.6684 mL 3.3418 mL 6.6836 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.3418 mL 16.7090 mL 33.4180 mL 83.5450 mL
5 mM 0.6684 mL 3.3418 mL 6.6836 mL 16.7090 mL
10 mM 0.3342 mL 1.6709 mL 3.3418 mL 8.3545 mL
15 mM 0.2228 mL 1.1139 mL 2.2279 mL 5.5697 mL
20 mM 0.1671 mL 0.8354 mL 1.6709 mL 4.1772 mL
25 mM 0.1337 mL 0.6684 mL 1.3367 mL 3.3418 mL
30 mM 0.1114 mL 0.5570 mL 1.1139 mL 2.7848 mL
40 mM 0.0835 mL 0.4177 mL 0.8354 mL 2.0886 mL
50 mM 0.0668 mL 0.3342 mL 0.6684 mL 1.6709 mL
60 mM 0.0557 mL 0.2785 mL 0.5570 mL 1.3924 mL
80 mM 0.0418 mL 0.2089 mL 0.4177 mL 1.0443 mL
100 mM 0.0334 mL 0.1671 mL 0.3342 mL 0.8354 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Durlobactam sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Durlobactam1467157-21-6ETX2514ETX 2514ETX-2514BacterialInhibitorinhibitorinhibit

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