1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. Tilpisertib

Tilpisertib  (Synonyms: GS-4875)

Cat. No.: HY-137456 Purity: 99.21%
COA Handling Instructions

Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689).

For research use only. We do not sell to patients.

Tilpisertib Chemical Structure

Tilpisertib Chemical Structure

CAS No. : 2065153-41-3

Size Price Stock Quantity
1 mg USD 980 In-stock
5 mg USD 2350 In-stock
10 mg USD 3800 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Description

Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689)[1].

IC50 & Target

serine/threonine kinase[1]

In Vitro

Tilpisertib is a serine/threonine kinase inhibitor[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

593.12

Formula

C33H33ClN8O

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC=CC([C@@H](C3=CN(N=N3)C4(C5)CC5C4)NC6=CC(C(NCC(C)(C)C)=C7C#N)=C(N=C7)C(Cl)=C6)=C2C=CN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (210.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6860 mL 8.4300 mL 16.8600 mL
5 mM 0.3372 mL 1.6860 mL 3.3720 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.21%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6860 mL 8.4300 mL 16.8600 mL 42.1500 mL
5 mM 0.3372 mL 1.6860 mL 3.3720 mL 8.4300 mL
10 mM 0.1686 mL 0.8430 mL 1.6860 mL 4.2150 mL
15 mM 0.1124 mL 0.5620 mL 1.1240 mL 2.8100 mL
20 mM 0.0843 mL 0.4215 mL 0.8430 mL 2.1075 mL
25 mM 0.0674 mL 0.3372 mL 0.6744 mL 1.6860 mL
30 mM 0.0562 mL 0.2810 mL 0.5620 mL 1.4050 mL
40 mM 0.0421 mL 0.2107 mL 0.4215 mL 1.0537 mL
50 mM 0.0337 mL 0.1686 mL 0.3372 mL 0.8430 mL
60 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7025 mL
80 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.5269 mL
100 mM 0.0169 mL 0.0843 mL 0.1686 mL 0.4215 mL
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Tilpisertib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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