Tilpisertib
Based on 1 Customer Validation
Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689).
For research use only. We do not sell to patients.
- Purity: 99.27%
- CAS No.: 2065153-41-3
- Formula: C33H33ClN8O
- Molecular Weight:593.12
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
serine/threonine kinase[1]
Tilpisertib is a serine/threonine kinase inhibitor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2065153-41-3
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Appearance Solid
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Molecular Weight 593.12
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Formula C33H33ClN8O
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Color Light yellow to yellow
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SMILES
O=C1C2=CC=CC([C@@H](C3=CN(N=N3)C4(C5)CC5C4)NC6=CC(C(NCC(C)(C)C)=C7C#N)=C(N=C7)C(Cl)=C6)=C2C=CN1C
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Synonyms
GS-4875
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (210.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. WO2017007689
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.6860 mL | 8.4300 mL | 16.8600 mL | 42.1500 mL |
| 5 mM | 0.3372 mL | 1.6860 mL | 3.3720 mL | 8.4300 mL | |
| 10 mM | 0.1686 mL | 0.8430 mL | 1.6860 mL | 4.2150 mL | |
| 15 mM | 0.1124 mL | 0.5620 mL | 1.1240 mL | 2.8100 mL | |
| 20 mM | 0.0843 mL | 0.4215 mL | 0.8430 mL | 2.1075 mL | |
| 25 mM | 0.0674 mL | 0.3372 mL | 0.6744 mL | 1.6860 mL | |
| 30 mM | 0.0562 mL | 0.2810 mL | 0.5620 mL | 1.4050 mL | |
| 40 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL | |
| 50 mM | 0.0337 mL | 0.1686 mL | 0.3372 mL | 0.8430 mL | |
| 60 mM | 0.0281 mL | 0.1405 mL | 0.2810 mL | 0.7025 mL | |
| 80 mM | 0.0211 mL | 0.1054 mL | 0.2107 mL | 0.5269 mL | |
| 100 mM | 0.0169 mL | 0.0843 mL | 0.1686 mL | 0.4215 mL |
Tilpisertib Related Classifications
HY-137456 Related Classifications
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