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  3. AA26-9

AA26-9 

Cat. No.: HY-18522 Purity: 98.03%
Handling Instructions

AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.

For research use only. We do not sell to patients.

AA26-9 Chemical Structure

AA26-9 Chemical Structure

CAS No. : 1312782-34-5

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10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
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10 mg USD 150 In-stock
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50 mg USD 450 In-stock
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100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AA26-9 is a potent and broad spectrum serine hydrolase inhibitor.

In Vitro

AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells[1].

Molecular Weight

166.18

Formula

C₇H₁₀N₄O

CAS No.

1312782-34-5

SMILES

O=C(N1N=NC=C1)N2CCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (601.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.0176 mL 30.0879 mL 60.1757 mL
5 mM 1.2035 mL 6.0176 mL 12.0351 mL
10 mM 0.6018 mL 3.0088 mL 6.0176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (15.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

AA26-9PhospholipaseInhibitorinhibitorinhibit

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AA26-9
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HY-18522
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