1312782-34-5
1312782-34-5
Chemical Structure
AA26-9
- CAS No.: 1312782-34-5
- Formula:C7H10N4O
- Molecular Weight:166.18
IUPAC Name: pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone
InChIKey: IFXGAMVQLDJRBQ-UHFFFAOYSA-N
SMILES: O=C(N1N=NC=C1)N2CCCC2
Biological Activity: AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines [1][2].
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AA26-9 | 99.83% | AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines . | ||||||||||||||||||||
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References
- [1]. Adibekian A, et al. Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol. 2011 May 15;7(7):469-78. [Content Brief]
- [2]. Borne AL, et al. Deciphering T Cell Immunometabolism with Activity-Based Protein Profiling. Curr Top Microbiol Immunol. 2019;420:175-210. [Content Brief]
Keywords
