Z-Pro-Pro-aldehyde-dimethyl acetal
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 170116-63-9
- Formula: C20H28N2O5
- Molecular Weight:376.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PREP 12 nM (IC50) |
Chemical Information
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CAS No. 170116-63-9
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Molecular Weight 376.45
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Formula C20H28N2O5
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Sequence
Pro-{Pro-Aldehyde-dimethyl acetal}
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Sequence Shortening
P-{Pro-Aldehyde-dimethyl acetal}
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Robin S B Williams, et al. A common mechanism of action for three mood-stabilizing drugs. Nature. 2002 May 16;417(6886):292-5. [Content Brief]
[2]. Andis Klegeris, et al. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP‐1 cell neurotoxicity. Glia. 2008 Apr 15;56(6):675-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z-Pro-Pro-aldehyde-dimethyl acetal Related Classifications
HY-P4308 Related Classifications
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