O-Phospho-L-serine-13C3,15N
O-Phospho-L-serine-13C3,15N is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
For research use only. We do not sell to patients.
- CAS No.: 2734706-69-3
- Formula: 13C3H8 15NO6P
- Molecular Weight:189.04
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2734706-69-3
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Unlabeled Cas 407-41-0
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Appearance Solid
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Molecular Weight 189.04
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Formula 13C3H8 15NO6P
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Color Off-white to light yellow
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SMILES
OP(O[13CH2][13C@H]([15NH2])[13C](O)=O)(O)=O
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Synonyms
L-Serine O-phosphate-13C3,15N; L-SOP-13C3,15N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 25 mg/mL (132.25 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (416 KB)
- English - EN (416 KB)
- Français - FR (416 KB)
- Deutsch - DE (416 KB)
- Norwegian - NO (416 KB)
- Español - ES (416 KB)
- Swedish - SV (416 KB)
- Italian - IT (416 KB)
- Korean - KR (416 KB)
- Portuguese - PT (416 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Kang HJ, et al. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30;290(5):2870-8. [Content Brief]
[3]. Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24;289(43):29961-74. [Content Brief]
[4]. Bailey TJ, et al. The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91(5):601-12. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.2899 mL | 26.4494 mL | 52.8989 mL | 132.2471 mL |
| 5 mM | 1.0580 mL | 5.2899 mL | 10.5798 mL | 26.4494 mL | |
| 10 mM | 0.5290 mL | 2.6449 mL | 5.2899 mL | 13.2247 mL | |
| 15 mM | 0.3527 mL | 1.7633 mL | 3.5266 mL | 8.8165 mL | |
| 20 mM | 0.2645 mL | 1.3225 mL | 2.6449 mL | 6.6124 mL | |
| 25 mM | 0.2116 mL | 1.0580 mL | 2.1160 mL | 5.2899 mL | |
| 30 mM | 0.1763 mL | 0.8816 mL | 1.7633 mL | 4.4082 mL | |
| 40 mM | 0.1322 mL | 0.6612 mL | 1.3225 mL | 3.3062 mL | |
| 50 mM | 0.1058 mL | 0.5290 mL | 1.0580 mL | 2.6449 mL | |
| 60 mM | 0.0882 mL | 0.4408 mL | 0.8816 mL | 2.2041 mL | |
| 80 mM | 0.0661 mL | 0.3306 mL | 0.6612 mL | 1.6531 mL | |
| 100 mM | 0.0529 mL | 0.2645 mL | 0.5290 mL | 1.3225 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
O-Phospho-L-serine-13C3,15N Related Classifications
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