TMPRSS6-IN-1
TMPRSS6-IN-1 (compound 8) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease). TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice.
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- CAS No.: 2088415-78-3
- Formule: C33H40N8O4S2
- Masse moléculaire:676.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
TMPRSS6 (Matriptase-2)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
18.1 nM
Compound: MD23; Cpd-8; A; TMPRSS6
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Disruption of epithelial integrity in human Caco-2 cells assessed as change in TEER modulation after 8 days
Disruption of epithelial integrity in human Caco-2 cells assessed as change in TEER modulation after 8 days
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[PMID: 39028865] |
Chemical Information
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CAS No. 2088415-78-3
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Masse moléculaire 676.85
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Formule C33H40N8O4S2
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SMILES
NC(NCCC[C@H](NC([C@@H](NC([C@@H](NC(CCC1=CC=CC=C1)=O)CC2=CSC=N2)=O)C(C)C)=O)C(C3=NC4=C(S3)C=CC=C4)=O)=N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TMPRSS6-IN-1 Related Classifications
HY-130136 Related Classifications
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