Suc-Phe-Ala-Ala-Phe-pNA (Synonyms: Suc-FAAF-pNA)

Name: Suc-Phe-Ala-Ala-Phe-pNA
Brand: MedChemExpress
SKU: HY-P4582
Rating: 4.5 (0 reviews)

Cat. No.: HY-P4582 Purity: 99.74%: Data Sheet
COA

SDS
Handling Instructions
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Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies.

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Custom Peptide Synthesis

Suc-Phe-Ala-Ala-Phe-pNA 화학구조

CAS No. : 110906-89-3

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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순도&문서
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제품 설명

In Vitro

Suc-Phe-Ala-Ala-Phe-pNA (50 μM; 5 h) is a substrate for processed Bacillus clausii NΔ18-ISP, which exhibits proteolytic activity toward it; Suc-Phe-Ala-Ala-Phe-pNA (4-75 μM) also enables quantification of N-terminal extension peptide inhibition of NΔ18-ISP with a K_i of 1 μM^[1].
Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the purified neutral metalloproteinase NPS from Saccharomonospora canescens sp. novus, strain 5 with a K_m of 14.5 μM, k_cat of 1.20 s^-1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

674.70

화학식

C₃₄H₃₈N₆O₉

CAS No.

110906-89-3

Appearance

Solid

Color

White to off-white

Sequence

Suc-Phe-Ala-Ala-Phe-pNA

Sequence Shortening

Suc-FAAF-pNA

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (148.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4821 mL	7.4107 mL	14.8214 mL
5 mM	0.2964 mL	1.4821 mL	2.9643 mL
10 mM	0.1482 mL	0.7411 mL	1.4821 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.74%

Select Batch:

Data Sheet (271 KB) SDS (254 KB)

COA (246 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Gamble M, et al. Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism. Proc Natl Acad Sci U S A. 2011;108(9):3536-3541.

[2]. Dolashka P, et al. A novel thermostable neutral proteinase from Saccharomonospora canescens. Biochim Biophys Acta. 1998;1382(2):207-216.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4821 mL	7.4107 mL	14.8214 mL	37.0535 mL
	5 mM	0.2964 mL	1.4821 mL	2.9643 mL	7.4107 mL
	10 mM	0.1482 mL	0.7411 mL	1.4821 mL	3.7054 mL
	15 mM	0.0988 mL	0.4940 mL	0.9881 mL	2.4702 mL
	20 mM	0.0741 mL	0.3705 mL	0.7411 mL	1.8527 mL
	25 mM	0.0593 mL	0.2964 mL	0.5929 mL	1.4821 mL
	30 mM	0.0494 mL	0.2470 mL	0.4940 mL	1.2351 mL
	40 mM	0.0371 mL	0.1853 mL	0.3705 mL	0.9263 mL
	50 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.7411 mL
	60 mM	0.0247 mL	0.1235 mL	0.2470 mL	0.6176 mL
	80 mM	0.0185 mL	0.0926 mL	0.1853 mL	0.4632 mL
	100 mM	0.0148 mL	0.0741 mL	0.1482 mL	0.3705 mL

Suc-Phe-Ala-Ala-Phe-pNA Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Suc-Phe-Ala-Ala-Phe-pNA (Synonyms: Suc-FAAF-pNA)

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Suc-Phe-Ala-Ala-Phe-pNA Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

Suc-Phe-Ala-Ala-Phe-pNA Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

Suc-Phe-Ala-Ala-Phe-pNA Related Classifications

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