110906-89-3
Chemical Structure
Suc-Phe-Ala-Ala-Phe-pNA
Synonym(s): Suc-FAAF-pNA
- CAS No.: 110906-89-3
- Formula:C34H38N6O9
- Molecular Weight:674.70
InChIKey: ICTPBQOIKFIIIX-MPPVQRIUSA-N
SMILES: [O-][N+](C(C=C1)=CC=C1NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](NC(CCC(O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O)=O
Biological Activity: Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies[1][2].
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Suc-Phe-Ala-Ala-Phe-pNA | 99.74% | Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies. | ||||||||||||||||||||
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- [1]. Gamble M, et al. Regulation of an intracellular subtilisin protease activity by a short propeptide sequence through an original combined dual mechanism. Proc Natl Acad Sci U S A. 2011;108(9):3536-3541. [Content Brief]
- [2]. Dolashka P, et al. A novel thermostable neutral proteinase from Saccharomonospora canescens. Biochim Biophys Acta. 1998;1382(2):207-216. [Content Brief]
Keywords
