1. Stem Cell/Wnt
  2. Wnt
  3. ARUK3001185

ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM.

For research use only. We do not sell to patients.

ARUK3001185 Chemical Structure

ARUK3001185 Chemical Structure

CAS No. : 2411969-39-4

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 220 In-stock
Solution
10 mM * 1 mL in DMSO USD 220 In-stock
Solid
5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 650 In-stock
50 mg USD 950 In-stock
100 mg USD 1350 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM[1].

IC50 & Target

IC50: 6.7 nM (Notum)[1]

Molecular Weight

282.05

Formula

C9H4Cl2F3N3

CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

FC(F)(C1=C(Cl)C=CC(N2C=CN=N2)=C1Cl)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (354.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5455 mL 17.7274 mL 35.4547 mL
5 mM 0.7091 mL 3.5455 mL 7.0909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5455 mL 17.7274 mL 35.4547 mL 88.6368 mL
5 mM 0.7091 mL 3.5455 mL 7.0909 mL 17.7274 mL
10 mM 0.3545 mL 1.7727 mL 3.5455 mL 8.8637 mL
15 mM 0.2364 mL 1.1818 mL 2.3636 mL 5.9091 mL
20 mM 0.1773 mL 0.8864 mL 1.7727 mL 4.4318 mL
25 mM 0.1418 mL 0.7091 mL 1.4182 mL 3.5455 mL
30 mM 0.1182 mL 0.5909 mL 1.1818 mL 2.9546 mL
40 mM 0.0886 mL 0.4432 mL 0.8864 mL 2.2159 mL
50 mM 0.0709 mL 0.3545 mL 0.7091 mL 1.7727 mL
60 mM 0.0591 mL 0.2955 mL 0.5909 mL 1.4773 mL
80 mM 0.0443 mL 0.2216 mL 0.4432 mL 1.1080 mL
100 mM 0.0355 mL 0.1773 mL 0.3545 mL 0.8864 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ARUK3001185 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ARUK3001185
Cat. No.:
HY-147519
Quantity:
MCE Japan Authorized Agent: