ARUK3001185
Based on 1 Customer Validation
ARUK3001185 is a potent, selective, orally active and brain-penetrant inhibitor of Notum (IC50 = 6.7 nM). ARUK3001185 can restore Wnt signaling in the presence of Notum in vitro. ARUK3001185 is selective against serine hydrolases, kinases, and drug targets. ARUK3001185 can be used to research the role of Notum plays in diseases.
For research use only. We do not sell to patients.
- Purity: 99.28%
- CAS No.: 2411969-39-4
- Formula: C9H4Cl2F3N3
- Molecular Weight:282.05
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Osteogenesis Compound Library
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Highly Selective Activators Library
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Extracellular Vesicles (EVs) Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Biological Activity
IC50: 6.7 nM (Notum)[1]
ARUK3001185 inhibits Notum with an IC50 of 6.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2411969-39-4
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Appearance Solid
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Molecular Weight 282.05
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Formula C9H4Cl2F3N3
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Color Off-white to pink
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SMILES
FC(F)(C1=C(Cl)C=CC(N2C=CN=N2)=C1Cl)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (354.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5455 mL | 17.7274 mL | 35.4547 mL | 88.6368 mL |
| 5 mM | 0.7091 mL | 3.5455 mL | 7.0909 mL | 17.7274 mL | |
| 10 mM | 0.3545 mL | 1.7727 mL | 3.5455 mL | 8.8637 mL | |
| 15 mM | 0.2364 mL | 1.1818 mL | 2.3636 mL | 5.9091 mL | |
| 20 mM | 0.1773 mL | 0.8864 mL | 1.7727 mL | 4.4318 mL | |
| 25 mM | 0.1418 mL | 0.7091 mL | 1.4182 mL | 3.5455 mL | |
| 30 mM | 0.1182 mL | 0.5909 mL | 1.1818 mL | 2.9546 mL | |
| 40 mM | 0.0886 mL | 0.4432 mL | 0.8864 mL | 2.2159 mL | |
| 50 mM | 0.0709 mL | 0.3545 mL | 0.7091 mL | 1.7727 mL | |
| 60 mM | 0.0591 mL | 0.2955 mL | 0.5909 mL | 1.4773 mL | |
| 80 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1080 mL | |
| 100 mM | 0.0355 mL | 0.1773 mL | 0.3545 mL | 0.8864 mL |
ARUK3001185 Related Classifications
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