2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. G12Si-1

G12Si-1 is a selective K-Ras(G12S) covalent inhibitor, which can inhibit oncogenic signaling of K-Ras(G12S). G12Si-1 shows good ability to covalently engage recombinant K-Ras(G12S) at the mutant serine residue. G12Si-1 can also affect nucleotide cycling of K-Ras by blocking Sos-catalyzed exchange and decreasing the rate of EDTA promoted exchange.

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G12Si-1 Chemical Structure

G12Si-1 Chemical Structure

CAS No. : 2946593-42-4

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G12Si-1 Related Antibodies

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K-Ras H-Ras Ras

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Description

G12Si-1 is a selective K-Ras(G12S) covalent inhibitor, which can inhibit oncogenic signaling of K-Ras(G12S). G12Si-1 shows good ability to covalently engage recombinant K-Ras(G12S) at the mutant serine residue. G12Si-1 can also affect nucleotide cycling of K-Ras by blocking Sos-catalyzed exchange and decreasing the rate of EDTA promoted exchange[1].

IC50 & Target

KRas G12S

 

Molecular Weight

534.05

Formula

C29H32ClN5O3
CAS No.
SMILES

ClC1=CC=CC2=CC=CC(N3CC4=C(CC3)C(N5CC(C6CC5)OC6=O)=NC(OC[C@@H]7CCCN7C)=N4)=C21
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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G12Si-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G12Si-12946593-42-4RasKRASK-RascancerG12Soncogenic signalingInhibitorinhibitorinhibit

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