2. Anti-infection
  3. Beta-lactamase Bacterial
  4. ANT3310 sodium

ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection.

For research use only. We do not sell to patients.

ANT3310 sodium Chemical Structure

ANT3310 sodium Chemical Structure

CAS No. : 2410688-61-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 110 In-stock
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Solid
5 mg USD 100 In-stock
10 mg USD 165 In-stock
25 mg USD 345 In-stock
50 mg USD 550 In-stock
100 mg USD 950 In-stock
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ANT3310 sodium Related Antibodies

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Description

ANT3310 sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). ANT3310 sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). ANT3310 sodium can be used in the research of bacterial infection[1][2].

In Vitro

ANT3310 sodium (Compound 21, 0.006 to 3 000 nM, 10 min) inhibits a series of Serine β-Lactamase (AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2), with IC<>50 values ranging from 1 nM to 175 nM[1].
ANT3310 sodium shows a low in vitro cytotoxicity (IC<>50: > 100 μM) in HepG2 cell, cardiotoxicity (inhibition of the hERG potassium ion channel), and genotoxicity (Ames test)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ANT3310 sodium Related Antibodies
In Vivo

ANT3310 sodium (intravenous injection, 25-100 mg/kg, at 1, 3, 5, and 7 h postinfection) reduces bacterial burdens in murine thigh infection model[1].
ANT3310 sodium (intravenous injection, 1 mg/kg, Male Swiss albino mice) shows a T1/2 value of 0.64 h, AUC value of 412 ng•h/mL, and Cl value of 40 mL/min/kg (pharmacokinetic assay)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine thigh infection model[1]
Dosage: 25, 50, and 100 mg/kg
Administration: Intravenous injection, at 1, 3, 5, and 7 h postinfection
Result: Reduced bacterial burdens (colony forming units, CFU) in a dose-dependent manner to levels below that of the initial starting inoculum at the highest dose, when treated with the combination of MEM.
Clinical Trial
Molecular Weight

262.19

Formula

C6H8FN2NaO5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(ON1[C@H]2C[N@]([C@@H](CC2)F)C1=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (953.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8140 mL 19.0701 mL 38.1403 mL
5 mM 0.7628 mL 3.8140 mL 7.6281 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8140 mL 19.0701 mL 38.1403 mL 95.3507 mL
5 mM 0.7628 mL 3.8140 mL 7.6281 mL 19.0701 mL
10 mM 0.3814 mL 1.9070 mL 3.8140 mL 9.5351 mL
15 mM 0.2543 mL 1.2713 mL 2.5427 mL 6.3567 mL
20 mM 0.1907 mL 0.9535 mL 1.9070 mL 4.7675 mL
25 mM 0.1526 mL 0.7628 mL 1.5256 mL 3.8140 mL
30 mM 0.1271 mL 0.6357 mL 1.2713 mL 3.1784 mL
40 mM 0.0954 mL 0.4768 mL 0.9535 mL 2.3838 mL
50 mM 0.0763 mL 0.3814 mL 0.7628 mL 1.9070 mL
60 mM 0.0636 mL 0.3178 mL 0.6357 mL 1.5892 mL
80 mM 0.0477 mL 0.2384 mL 0.4768 mL 1.1919 mL
100 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9535 mL
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ANT3310 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANT33102410688-61-6ANT 3310ANT-3310Beta-lactamaseBacterialβ-lactamaseDBOsSBLCRECRABOXA enzymesβ-lactam antibioticinfectionInhibitorinhibitorinhibit

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