2410688-61-6
Chemical Structure
Pilabactam sodium
Synonym(s): ANT3310 sodium
- CAS No.: 2410688-61-6
- Formula:C6H8FN2NaO5S
- Molecular Weight:262.19
IUPAC Name: sodium (1S,2R,5R)-2-fluoro-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
InChIKey: UIJIKXQAJBMNIR-JBUOLDKXSA-M
SMILES: O=S(ON1[C@H]2C[N@]([C@@H](CC2)F)C1=O)(O[Na])=O
Biological Activity: Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection[1][2].
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Pilabactam sodium | 99.54% | Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection. | ||||||||||||||||||||
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- [1]. David T Davies, et al. Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii. J Med Chem. 2020 Dec 24;63(24):15802-15820. [Content Brief]
Keywords
