1. Protein Tyrosine Kinase/RTK
  2. ALK
    FAK
  3. ALK inhibitor 2

ALK inhibitor 2 

Cat. No.: HY-15358 Purity: 99.77%
Handling Instructions

ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM).

For research use only. We do not sell to patients.

ALK inhibitor 2 Chemical Structure

ALK inhibitor 2 Chemical Structure

CAS No. : 761438-38-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 350 In-stock
Estimated Time of Arrival: December 31
5 mg USD 307 In-stock
Estimated Time of Arrival: December 31
10 mg USD 430 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ALK inhibitor 2 (compound 18) is a potent pyrimidin ALK inhibitor. ALK inhibitor 2 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=37 nM) and focal adhesion kinase (FAK; IC50=5 nM)[1].

IC50 & Target

IC50: 37 nM (TSSK2) and 5 nM (FAK)[1]

In Vitro

Testis-specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. ALK inhibitor 2 (compound 18) contains a methylpiperazine A ring (R1=Me, X=N) and a D ring with R5=methylsulfonamide. ALK inhibitor 2 can undergo metabolic oxidation to form reactive adducts in the presence of glutathione[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.03

Formula

C₂₃H₂₈ClN₇O₃S

CAS No.

761438-38-4

SMILES

O=S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC)C=C(N4CCN(C)CC4)C=C3)=N2)C=CC=C1)(NC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (96.52 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9304 mL 9.6519 mL 19.3039 mL
5 mM 0.3861 mL 1.9304 mL 3.8608 mL
10 mM 0.1930 mL 0.9652 mL 1.9304 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.77%

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Keywords:

ALK inhibitor 2ALK inhibitor2ALK inhibitor-2ALKFAKAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinasetestis-specificserine/threoninekinase2TSSK2focaladhesionreversiblemalecontraceptionInhibitorinhibitorinhibit

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ALK inhibitor 2
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HY-15358
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