MKI-1
Based on 1 publication(s) in Google Scholar
MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.13%
- CAS. Nr.: 1190277-80-5
- Formel: C18H14N4O
- Molecular Weight:302.33
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) MKI-1
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Biologische Aktivität
MKI-1 (5-20 μM) inhibits the activity of MASTL in breast cancer cells[1].
MKI-1 (100 μM, 72 h) inhibits various oncogenic properties of breast cancer cells but showed much weaker effects on the viability of normal breast cells[1].
MKI-1 clearly reduces both serine 62-phosphorylation of c-Myc and total c-Myc, with a decrease in ENSA phosphorylation[1].
MKI-1 (20 μM, 16 h) reduces c-Myc stability through PP2A activation in MCF7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF7 and T47D cells.
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Concentration:5-20 μM.
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Incubation Time:24 h.
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Result:Inhibited the phosphorylation of ENSA in MCF7 and T47D cells.
Significantly inhibited the phosphorylation of ENSA in mitotic cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old female BALB/c nude mice (BT549 cells)[1].
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Dosage:50 mg/kg.
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Administration:Twice per week by intraperitoneal (i.p.) injection.
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Result:Reduced tumor growth.
Chemical Information
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CAS. Nr. 1190277-80-5
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Appearance Solid
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Molecular Weight 302.33
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Formel C18H14N4O
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Color Off-white to light yellow
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SMILES
O=C(NC1=NC2=CC=CC=C2N1)C3=CC=CC(N4C=CC=C4)=C3
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Synonyms
MASTL Kinase Inhibitor-1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (826.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3076 mL | 16.5382 mL | 33.0764 mL | 82.6911 mL |
| 5 mM | 0.6615 mL | 3.3076 mL | 6.6153 mL | 16.5382 mL | |
| 10 mM | 0.3308 mL | 1.6538 mL | 3.3076 mL | 8.2691 mL | |
| 15 mM | 0.2205 mL | 1.1025 mL | 2.2051 mL | 5.5127 mL | |
| 20 mM | 0.1654 mL | 0.8269 mL | 1.6538 mL | 4.1346 mL | |
| 25 mM | 0.1323 mL | 0.6615 mL | 1.3231 mL | 3.3076 mL | |
| 30 mM | 0.1103 mL | 0.5513 mL | 1.1025 mL | 2.7564 mL | |
| 40 mM | 0.0827 mL | 0.4135 mL | 0.8269 mL | 2.0673 mL | |
| 50 mM | 0.0662 mL | 0.3308 mL | 0.6615 mL | 1.6538 mL | |
| 60 mM | 0.0551 mL | 0.2756 mL | 0.5513 mL | 1.3782 mL | |
| 80 mM | 0.0413 mL | 0.2067 mL | 0.4135 mL | 1.0336 mL | |
| 100 mM | 0.0331 mL | 0.1654 mL | 0.3308 mL | 0.8269 mL |
MKI-1 Related Classifications
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