2. Metabolic Enzyme/Protease
  3. Phosphoglycerate Dehydrogenase (PHGDH)
  4. PHGDH-IN-2

PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells.

For research use only. We do not sell to patients.

PHGDH-IN-2 Chemical Structure

PHGDH-IN-2 Chemical Structure

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PHGDH-IN-2 Related Antibodies

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Description

PHGDH-IN-2 is a potent and NAD+ competitive PHGDH inhibitor with an IC50 of 5.2 µM. PHGDH-IN-2 inhibits the serine synthetic pathway in MDA-MB-468 cells. PHGDH-IN-2 inhibits the growth of PHGDH-dependent cancer cells[1].

IC50 & Target

PHGDH[1]
In Vitro

PHGDH-IN-2 (compound C25) (10, 30 µM) inhibits the serine synthetic pathway in MDA-MB-468 cells[1].
PHGDH-IN-2 (72 h) inhibits the growth of PHGDH-dependent cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHGDH-IN-2 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, NCI-H1975, HCC827, PC-9, ZR-75–1, MDA-MB-231 cells
Concentration:
Incubation Time: 72 h
Result: Inhibited the growth of PHGDH-dependent cancer cells.
Molecular Weight

420.48

Formula

C22H20N4O3S
SMILES

CN1C(C(NC2=CC=CC(NS(=O)(C3=CC=C(C=C3)N)=O)=C2)=O)=CC4=C1C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PHGDH-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHGDH-IN-2Phosphoglycerate Dehydrogenase (PHGDH)competitiveantitumorStructure-activity relationshipsserine synthetic pathwayvirtual screeningselectiveInhibitorinhibitorinhibit

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