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Tolterodine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cytochrome P450 (6) Drug Intermediate (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (14) mAChR (20) Reference Standards (4)
By Research Areas:	Cancer (6) Neurological Disease (18)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-76569

Desfesoterodine 1 Publications Verification PNU-200577; 5-Hydroxymethyl Tolterodine	mAChR	Neurological Disease Cancer
Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-A0024

*Tolterodine* (R)-(+)-Tolterodine; (+)-Tolterodine; (R)-Tolterodine; PNU-200583	mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder .

HY-90010

Tolterodine tartrate Kabi-2234; PNU-200583E	mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine tartrate (Kabi-2234) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine tartrate competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine tartrate restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine tartrate ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine tartrate can be used for the research of urinary tract infections and overactive bladder .

HY-76570

(Rac)-5-Hydroxymethyl Tolterodine (Rac)-Desfesoterodine; (Rac)-PNU-200577	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (K_i values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-76996

Tolterodine impurity 1	Drug Intermediate	Others
Tolterodine impurity 1 is an impurity of Tolterodine (HY-A0024).

HY-118399

PNU-200579	Endogenous Metabolite	Others
PNU-200579 is a metabolite of Tolterodine (HY-A0024) in dog urine .

HY-76569R

Desfesoterodine (Standard) PNU-200577 (Standard); 5-Hydroxymethyl Tolterodine (Standard)	Reference Standards mAChR	Neurological Disease
Desfesoterodine (Standard) is the analytical standard of Desfesoterodine. This product is intended for research and analytical applications. Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-76570A

*(Rac)-5-Hydroxymethyl Tolterodine* hydrochloride** (Rac)-Desfesoterodine hydrochloride; (Rac)-PNU-200577 hydrochloride	mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride, an active metabolite of Tolterodine, is a mAChR antagonist (K_i values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research .

HY-A0024R

Tolterodine (Standard) (R)-(+)-Tolterodine (Standard); (+)-Tolterodine (Standard); (R)-Tolterodine (Standard); PNU-200583 (Standard)	Reference Standards mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine (Standard) is the analytical standard of Tolterodine. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-A0024S

Tolterodine-d14 hydrochloride (R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride	Isotope-Labeled Compounds mAChR Cytochrome P450	Neurological Disease
Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-W708197

Tolterodine dimer	mAChR	Neurological Disease
Tolterodine dimer is the impurity of Tolterodine (HY-A0024). Tolterodine is a potent muscarinic receptor antagonist.

HY-A0024AS1

*(Rac)-Tolterodine-d5*	mAChR Isotope-Labeled Compounds	Others
(Rac)-Tolterodine-d₅ is deuterium labeled (rac)-Tolterodine.

HY-132645S

*(Rac)-Tolterodine-d14 hydrochloride*	Isotope-Labeled Compounds	Others
(Rac)-Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled (Rac)-Tolterodine hydrochloride .

HY-132636S

*(Rac)-5-Carboxy tolterodine-d14*	Isotope-Labeled Compounds	Others
(Rac)-5-Carboxy Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Carboxy Tolterodine .

HY-W704036

Tolterodine Ep Impurity D-d7 rac Desisopropyl Tolterodine methyl ether-d₇	Isotope-Labeled Compounds	Others
Tolterodine Ep Impurity D-d₇ (rac Desisopropyl tolterodine methyl ether-d₇) is the deuterium labeled Tolterodine Ep Impurity D (HY-Z12547).

HY-W703068

*Rac desisopropyl tolterodine-d7*	Isotope-Labeled Compounds	Others
Rac desisopropyl tolterodine-d₇ is the deuterium labeled 2-(3-(Isopropylamino)-1-phenylpropyl)-4-methylphenol (Tolterodine Impurity) (HY-Z8824).

HY-W700319

(Rac)-5-Carboxy tolterodine	mAChR	Neurological Disease
(Rac)-5-Carboxy tolterodine is an inactive metabolite of the muscarinic acetylcholine receptor antagonist Tolterodine (HY-A0024).

HY-76570S1

*5-Hydroxymethyl Tolterodine-d14 formate*	Isotope-Labeled Compounds mAChR	Neurological Disease
5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-132353S

*(Rac)-5-Carboxy desisopropyl tolterodine-d7*	Isotope-Labeled Compounds	Others
(Rac)-5-Carboxy desisopropyl tolterodine-d₇ is the deuterium labeled (Rac)-5-Carboxy desisopropyl tolterodine .

HY-W309130

(S)-Tolterodine	mAChR	Neurological Disease
(S)-Tolterodine is a muscarinic acetylcholine receptor (mAChR) inhibitor, with an IC₅₀ of 588 nM .

HY-76569B

*5-Hydroxymethyl tolterodine* formate** PNU-200577 formic	mAChR	Neurological Disease
5-Hydroxymethyl tolterodine (formate) (PNU-200577 (formic)) is an active metabolite of the muscarinic acetylcholine receptor antagonists Tolterodine (HY-A0024) and Fesoterodine (HY-70053). 5-Hydroxymethyl tolterodine (formate) is formed from tolterodine by the cytochrome P450 (CYP) isoform CYP2D6 and from fesoterodine by plasma esterases.

HY-90010R

Tolterodine tartrate (Standard) Kabi-2234 (Standard); PNU-200583E (Standard)	Reference Standards mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine (tartrate) (Standard) is the analytical standard of Tolterodine tartrate. This product is intended for research and analytical applications. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-76569S1

(R)-Hydroxytolterodine-d14 PNU-200577-d₁₄; 5-Hydroxymethyl Tolterodine-d₁₄	mAChR Isotope-Labeled Compounds	Neurological Disease
(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-A0024AS

*(Rac)-Tolterodine-d14 tartrate* (Rac)-PNU-200583-d14 tartrate	mAChR Isotope-Labeled Compounds	Others
(Rac)-Tolterodine-d₁₄ (tartrate) is the deuterium labeled (Rac)-Tolterodine tartrate .

HY-76996S1

*(S)-5-Hydroxymethyl Tolterodine-d14 formate*	Isotope-Labeled Compounds	Others
(S)-5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol.

HY-76570S

*(Rac)-5-Hydroxymethyl Tolterodine-d14* (Rac)-Desfesoterodine-d₁₄; (Rac)-PNU-200577-d₁₄	Isotope-Labeled Compounds mAChR	Neurological Disease
(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-76570S2

*(Rac)-5-Hydroxymethyl tolterodine-d5* (Rac)-Desfesoterodine-d₅; (Rac)-PNU-200577-d₅	mAChR Isotope-Labeled Compounds	Neurological Disease
(Rac)-5-hydroxymethyl Tolterodine-d₅ ((Rac)-Desfesoterodine-d₅; (Rac)-PNU-200577-d₅) is deuterium-labeled (Rac)-5-Hydroxymethyl Tolterodine (HY-76570) .

HY-90010S

Tolterodine tartrate-d14 Kabi-2234-d₁₄; PNU-200583E-d₁₄	Isotope-Labeled Compounds mAChR Cytochrome P450	Neurological Disease Cancer
Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-76996R

Tolterodine impurity 1 (Standard)	Reference Standards
(S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol (Standard) is the analytical standard of (S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol. This product is intended for research and analytical applications.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-118399

PNU-200579	Structural Classification Alkaloids Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Other Alkaloids Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PNU-200579 is a metabolite of Tolterodine (HY-A0024) in dog urine .

Cat. No.	Product Name	Chemical Structure

HY-A0024S

Tolterodine-d14 hydrochloride
Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Tolterodine-d14 hydrochloride

Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled Tolterodine hydrochloride . Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

HY-A0024AS1

*(Rac)-Tolterodine-d5*
(Rac)-Tolterodine-d₅ is deuterium labeled (rac)-Tolterodine.

HY-132645S

*(Rac)-Tolterodine-d14 hydrochloride*
(Rac)-Tolterodine-d₁₄ (hydrochloride) is the deuterium labeled (Rac)-Tolterodine hydrochloride .

HY-132636S

*(Rac)-5-Carboxy tolterodine-d14*
(Rac)-5-Carboxy Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Carboxy Tolterodine .

HY-W704036

Tolterodine Ep Impurity D-d7
Tolterodine Ep Impurity D-d₇ (rac Desisopropyl tolterodine methyl ether-d₇) is the deuterium labeled Tolterodine Ep Impurity D (HY-Z12547).

HY-W703068

*Rac desisopropyl tolterodine-d7*
Rac desisopropyl tolterodine-d₇ is the deuterium labeled 2-(3-(Isopropylamino)-1-phenylpropyl)-4-methylphenol (Tolterodine Impurity) (HY-Z8824).

HY-76570S1

*5-Hydroxymethyl Tolterodine-d14 formate*
5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

5-Hydroxymethyl Tolterodine-d14 formate

5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-132353S

*(Rac)-5-Carboxy desisopropyl tolterodine-d7*
(Rac)-5-Carboxy desisopropyl tolterodine-d₇ is the deuterium labeled (Rac)-5-Carboxy desisopropyl tolterodine .

HY-76569S1

(R)-Hydroxytolterodine-d14
(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

(R)-Hydroxytolterodine-d14

(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-A0024AS

*(Rac)-Tolterodine-d14 tartrate*
(Rac)-Tolterodine-d₁₄ (tartrate) is the deuterium labeled (Rac)-Tolterodine tartrate .

HY-76996S1

*(S)-5-Hydroxymethyl Tolterodine-d14 formate*
(S)-5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (S)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenol.

HY-76570S

*(Rac)-5-Hydroxymethyl Tolterodine-d14*
(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

(Rac)-5-Hydroxymethyl Tolterodine-d14

(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research .

HY-76570S2

*(Rac)-5-Hydroxymethyl tolterodine-d5*
(Rac)-5-hydroxymethyl Tolterodine-d₅ ((Rac)-Desfesoterodine-d₅; (Rac)-PNU-200577-d₅) is deuterium-labeled (Rac)-5-Hydroxymethyl Tolterodine (HY-76570) .

HY-90010S

Tolterodine tartrate-d14
Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Tolterodine tartrate-d14

Tolterodine tartrate-d₁₄ (Kabi-2234-d₁₄) is deuterium labeled Tolterodine tartrate. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

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