Tolterodine-d14 hydrochloride
Based on 1 Customer Validation
Tolterodine-d14 (hydrochloride) is the deuterium labeled Tolterodine hydrochloride. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 1217645-16-3
- Formula: C22H18D14ClNO
- Molecular Weight:376.03
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217645-16-3
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Unlabeled Cas 124937-51-5
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Appearance Solid
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Molecular Weight 376.03
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Formula C22H18D14ClNO
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])N(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CC[C@H](C1=CC=CC=C1)C2=C(C=CC(C)=C2)O.Cl
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Synonyms
(R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
Ethanol : 120 mg/mL (319.12 mM; Need ultrasonic)
DMSO : 100 mg/mL (265.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Nilvebrant L. Tolterodine and its active 5-hydroxymethyl metabolite: pure muscarinic receptor antagonists. Pharmacol Toxicol. 2002 May;90(5):260-7. [Content Brief]
[3]. Andersson SH, et al. Biotransformation of tolterodine, a new muscarinic receptor antagonist, in mice, rats, and dogs. Drug Metab Dispos. 1998 Jun;26(6):528-35. [Content Brief]
[4]. Cappon GD, et al. Tolterodine does not affect memory assessed by passive-avoidance response test in mice. Eur J Pharmacol. 2008 Jan 28;579(1-3):225-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 2.6594 mL | 13.2968 mL | 26.5936 mL | 66.4841 mL |
| 5 mM | 0.5319 mL | 2.6594 mL | 5.3187 mL | 13.2968 mL | |
| 10 mM | 0.2659 mL | 1.3297 mL | 2.6594 mL | 6.6484 mL | |
| 15 mM | 0.1773 mL | 0.8865 mL | 1.7729 mL | 4.4323 mL | |
| 20 mM | 0.1330 mL | 0.6648 mL | 1.3297 mL | 3.3242 mL | |
| 25 mM | 0.1064 mL | 0.5319 mL | 1.0637 mL | 2.6594 mL | |
| 30 mM | 0.0886 mL | 0.4432 mL | 0.8865 mL | 2.2161 mL | |
| 40 mM | 0.0665 mL | 0.3324 mL | 0.6648 mL | 1.6621 mL | |
| 50 mM | 0.0532 mL | 0.2659 mL | 0.5319 mL | 1.3297 mL | |
| 60 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1081 mL | |
| 80 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.8311 mL | |
| 100 mM | 0.0266 mL | 0.1330 mL | 0.2659 mL | 0.6648 mL |
Tolterodine-d14 hydrochloride Related Classifications
HY-A0024S Related Classifications
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