2. Others GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds mAChR Cytochrome P450
  4. Tolterodine-d14 hydrochloride

Tolterodine-d14 hydrochloride  (Synonyms: (R)-(+)-Tolterodine-d14 hydrochloride; (+)-Tolterodine-d14 hydrochloride; (R)-Tolterodine-d14 hydrochloride; PNU-200583-d14 hydrochloride)

Cat. No.: HY-A0024S Pureza: 99.0%
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Tolterodine-d14 (hydrochloride) is the deuterium labeled Tolterodine hydrochloride. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

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Tolterodine-d<sub>14</sub> hydrochloride

Tolterodine-d14 hydrochloride Estructura química

No. CAS : 1217645-16-3

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg   Obtener un presupuesto  
10 mg   Obtener un presupuesto  

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Based on 1 publication(s) in Google Scholar

Other Forms of Tolterodine-d14 hydrochloride:

Tolterodine-d14 hydrochloride Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas mAChR:

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

Ver todos los productos específicos de isoformas Cytochrome P450:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Descripciòn

Tolterodine-d14 (hydrochloride) is the deuterium labeled Tolterodine hydrochloride[1]. Tolterodine ((R)-(+)-Tolterodine) is a mAChR inhibitor and substrate for cytochrome P450 enzymes. Tolterodine competitively binds acetylcholine, reduces sympathetic excitation, and inhibits involuntary bladder muscle contraction. Tolterodine restores the Nrf2/NF-κB signaling pathway, mediates protection against inflammatory response and ferroptosis. Tolterodine ameliorates LPS (HY-D1056)-induced reactive oxygen species production and lipid oxidation. Tolterodine can be used for the research of urinary tract infections and overactive bladder.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tolterodine-d14 hydrochloride Related Antibodies
Peso molecular

376.03

Fòrmula

C22H18D14ClNO
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])N(C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])CC[C@H](C1=CC=CC=C1)C2=C(C=CC(C)=C2)O.Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

Ethanol : 120 mg/mL (319.12 mM; Need ultrasonic)

DMSO : 100 mg/mL (265.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6594 mL 13.2968 mL 26.5936 mL
5 mM 0.5319 mL 2.6594 mL 5.3187 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol 1 mM 2.6594 mL 13.2968 mL 26.5936 mL 66.4841 mL
5 mM 0.5319 mL 2.6594 mL 5.3187 mL 13.2968 mL
10 mM 0.2659 mL 1.3297 mL 2.6594 mL 6.6484 mL
15 mM 0.1773 mL 0.8865 mL 1.7729 mL 4.4323 mL
20 mM 0.1330 mL 0.6648 mL 1.3297 mL 3.3242 mL
25 mM 0.1064 mL 0.5319 mL 1.0637 mL 2.6594 mL
30 mM 0.0886 mL 0.4432 mL 0.8865 mL 2.2161 mL
40 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6621 mL
50 mM 0.0532 mL 0.2659 mL 0.5319 mL 1.3297 mL
60 mM 0.0443 mL 0.2216 mL 0.4432 mL 1.1081 mL
80 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8311 mL
100 mM 0.0266 mL 0.1330 mL 0.2659 mL 0.6648 mL
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Tolterodine-d14 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolterodine-d141217645-16-3(R)-(+)-Tolterodine-d14(+)-Tolterodine-d14(R)-Tolterodine-d14PNU-200583-d14Isotope-Labeled CompoundsmAChRCytochrome P450Muscarinic acetylcholine receptorCYPsInhibitorinhibitorinhibit

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Nombre del producto:
Tolterodine-d14 hydrochloride
Cat. No.:
HY-A0024S
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