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Results for "

VAD

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (4) Autophagy (1) Caspase (16) Epigenetic Reader Domain (1) Glutathione Peroxidase (2) Keap1-Nrf2 (1) Necroptosis (3) NF-κB (1) NOD-like Receptor (NLR) (1) PI3K (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) RIP kinase (2) SARS-CoV (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (5) Neurological Disease (4)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658B

*Z-VAD-FMK* Maximum Cited Publications 740 Publications Verification Z-VAD(OH)-FMK	Caspase Apoptosis RIP kinase Glutathione Peroxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-16658

*Z-VAD(OMe)-FMK* 195+ Cited Publications Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor . Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1 .

HY-14909

Bardoxolone 20+ Cited Publications CDDO; RTA 401	Keap1-Nrf2 NF-κB SARS-CoV Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Necroptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma .

HY-164388

Z-VAD 15+ Cited Publications	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

HY-P1008

Z-VDVAD-FMK 5 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

HY-151527

PI3K/Akt/CREB activator 1 4 Publications Verification	Akt PI3K Epigenetic Reader Domain	Neurological Disease
PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD) .

HY-100894

*Biotin-VAD-FMK* 1 Publications Verification	Caspase	Cancer
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders, such as vascular dementia (VaD) .

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-P1008A

Z-VDVA-(DL-Asp)-FMK Z-VD(OMe)VAD(OMe)-(DL-Asp)-FMK	Caspase	Cancer
Z-VDVA-(DL-Asp)-FMK is a Z-VDVAD-FMK derivative. Z-VDVAD-FMK (HY-P1008) is a special inhibitor of caspase-2 .

HY-P10084

*Ac-VAD-pNA*	Caspase	Others
Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

HY-P10243

*Ac-VAD-CMK*	Caspase	Neurological Disease
Ac-VAD-CMK is a pan inhibitor for caspase 1 .

HY-P4392

*Z-VAD-AMC*	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-P10276

*Ac-VAD-AFC*	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-W011254

*Ac-VAD-CHO* Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-P0110

*(Iso)-Z-VAD(OMe)-FMK* (Iso)-Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .

HY-P10955

Ac-AAVALLPAVLLALLAPVAD-CHO TFA	Caspase	Others
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a composite of Ac-VAD-CHO. Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a non-selective caspase inhibitor as well as a cell permeable hydrophobic sequence derived from K-FGF .

HY-163390

RIP1 kinase inhibitor 9	RIP kinase Necroptosis	Inflammation/Immunology Cancer
RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis in HT-29 cells with an EC₅₀ of 7.04 nM .

HY-100894R

*Biotin-VAD-FMK (Standard)*	Caspase Reference Standards	Cancer
Biotin-VAD-FMK (Standard) is the analytical standard of Biotin-VAD-FMK (HY-100894). This product is intended for research and analytical applications. Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

HY-17678

*Z-VAD-CHO*	Caspase	Inflammation/Immunology
Z-VAD-CHO is a potent inhibitor of human caspase-1 with a K_i value of 0.008 μM .

Cat. No.	Product Name	Type

HY-16658BG

Z-VAD-FMK	Fluorescent Dye
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Fluorescent Dye

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Cat. No.	Product Name	Type

HY-100894

*Biotin-VAD-FMK* 1 Publications Verification	Biochemical Assay Reagents
Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

HY-16658BG

Z-VAD-FMK	Biochemical Assay Reagents
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

Z-VAD-FMK

Biochemical Assay Reagents

HY-100894R

*Biotin-VAD-FMK (Standard)*	Biochemical Assay Reagents
Biotin-VAD-FMK (Standard) is the analytical standard of Biotin-VAD-FMK (HY-100894). This product is intended for research and analytical applications. Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Cat. No.	Product Name	Target	Research Area

HY-164388

Z-VAD 15+ Cited Publications	Caspase Apoptosis Autophagy Necroptosis	Cardiovascular Disease Cancer
Z-VAD is an irreversible, broad-spectrum pan-caspase inhibitor that can inhibit a variety of caspases including caspase-3, -6, -7, -8, -9, etc. (with a weaker inhibitory effect on caspase-2). Z-VAD can block apoptosis signaling pathways, induce autophagy and necrosis in tumor cells, and has anti-angiogenic activity. Z-VAD can enhance the sensitivity of breast cancer and lung cancer cells to radiotherapy in vitro and in vivo, and prolong the growth delay of tumor xenograft models. Z-VAD is well tolerated and is mainly used in research related to cancer radiosensitization and cell death pathway regulation .

HY-P1008

Z-VDVAD-FMK 5 Publications Verification Z-VD(OMe)VAD(OMe)-FMK	Caspase	Cancer
Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis .

HY-P10084

*Ac-VAD-pNA*	Caspase	Others
Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

HY-P10243

*Ac-VAD-CMK*	Caspase	Neurological Disease
Ac-VAD-CMK is a pan inhibitor for caspase 1 .

HY-P4392

*Z-VAD-AMC*	Caspase	Others
Z-VAD-AMC is a substrate of caspase-9 .

HY-P10276

*Ac-VAD-AFC*	Caspase	Cancer
Ac-VAD-AFC is a fluorescent substrate for caspases and can be used to test the activity of caspases .

HY-W011254

*Ac-VAD-CHO* Ac-Val-Ala-Asp-CHO	Caspase	Cancer
Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO) is a pan-caspase inhibitor. Ac-VAD-CHO inhibits dissipation of MMP and cytochrome c release in hypoxia-exposed cells .

HY-P0110

*(Iso)-Z-VAD(OMe)-FMK* (Iso)-Z-Val-Ala-Asp(OMe)-FMK	Caspase	Cancer
(Iso)-Z-VAD(OMe)-FMK ((Iso)-Z-Val-Ala-Asp(OMe)-FMK) is an isomer of the caspase and UCHL1 inhibitor Z-VAD(OMe)-FMK (HY-16658) .

HY-P10955

Ac-AAVALLPAVLLALLAPVAD-CHO TFA	Caspase	Others
Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a composite of Ac-VAD-CHO. Ac-AAVALLPAVLLALLAPVAD-CHO (TFA) is a non-selective caspase inhibitor as well as a cell permeable hydrophobic sequence derived from K-FGF .

HY-100894R

*Biotin-VAD-FMK (Standard)*	Caspase Reference Standards	Cancer
Biotin-VAD-FMK (Standard) is the analytical standard of Biotin-VAD-FMK (HY-100894). This product is intended for research and analytical applications. Biotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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