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Results for "

aqueous+solubility

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (3) Apoptosis (1) Biochemical Assay Reagents (6) Caspase (1) Dihydroorotate Dehydrogenase (1) Gli (1) GLP Receptor (1) HBV (1) Hedgehog (1) Liposome (1) LPL Receptor (1) Oxytocin Receptor (1) Parasite (1) PROTAC Linkers (2) ROR (1) Sigma Receptor (1) Smo (1)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	DBCO (2) Azide (2)
Oligonucleotides:	Pegylated Lipids (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W591374

DBCO-PEG4-Val-Ala-PAB-PNP	ADC Linker	Cancer
DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.

HY-P4389

(Asp28)-Glucagon (1-29) (human, rat, porcine)	GLP Receptor	Metabolic Disease
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .

HY-151392

LPA5 antagonist 2	LPL Receptor	Neurological Disease Inflammation/Immunology
LPA5 antagonist 2 (compound 65) is a high aqueous solubility LPA5 (lysophosphatidic acid receptor 5) antagonist. LPA5 antagonist 2 significantly attenuates nociceptive hypersensitivity and it can be used for the research of inflammatory and neuropathic pains .

HY-W591373

DBCO-PEG4-Val-Ala-PAB	ADC Linker	Cancer
DBCO-PEG4-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility.

HY-145261

hDHODH-IN-8	Dihydroorotate Dehydrogenase	Inflammation/Immunology
hDHODH-IN-8 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC₅₀ of 16 nM. hDHODH-IN-8 has potent antiproliferative activity and excellent aqueous solubility. hDHODH-IN-8 has the potential for the research of tumor disease, especially lymphoma .

HY-W800669

(S,R,S)-AHPC-PEG2-NHS ester	PROTAC Linkers	Cancer
(S, R, S)-AHPC-PEG2-NHS ester is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG linker to empower PROTAC medicine chemistry. NHS ester is reactive with amine moiety. The hydrophilic PEG spacer increases its aqueous solubility.

HY-W190942

(S,R.S)-AHPC-PEG8-acid	PROTAC Linkers	Cancer
(S, R, S)-AHPC-PEG8-acid is a synthetic PROTAC linker that incorporatess an E3 ligase ligand with a PEG8 linker to empower PROTAC drug R&D. PEG8 increases the compound's aqueous solubility. Acid group is reactive with amine containing molecule.

HY-126321

RORγt agonist 1	ROR	Cancer
RORγt agonist 1 (compound 14) is a potent, orally bioavailable RORγt agonist with an EC₅₀ of 20.8 nM. RORγt agonist 1 showes high metabolic stability, improved aqueous solubility and excellent mouse PK profile. RORγt agonist 1 is a potential candidate of RORγt agonist for cancer immunotherapy .

HY-152614

Antimalarial agent 19	Parasite	Infection
Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC₅₀ values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine .

HY-W800814

Azido-PEG8-Amido-Val-Cit-PAB	ADC Linker	Cancer
Azido-PEG8-Amido-Val-Cit-PAB is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Azido will react with DBCO, BCN or other alkyne groups through click chemistry. PEG spacer increases aqueous solubility. Reagent grade, for research purpose.

HY-151134

HBV-IN-25	HBV	Infection
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC₅₀ values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity .

HY-W440807

Oleoyl-Gly-Lys-(m-PEG11)-NH2	Liposome	Others
Oleoyl-Gly-Lys-(m-PEG11)-NH2 is a PEG-lipid molecule featuring an oleoyl amide linked to a Gly-Lys dipeptide and a methoxy PEG11 chain on the C-terminus of the lysine. The lysine primary amine may be used in a wide variety of reactions with carboxylic acids, NHS esters, and carbonyl groups. The PEG linker provides aqueous solubility.

HY-W800649

Aminooxy-PEG2-amine hydrochloride	Biochemical Assay Reagents	Others
Aminooxy-PEG2-amine hydrochloride (compound L3) is an aqueous soluble crosslinker. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond, if a reductant is used, it will form a hydroxylamine linkage. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term .

HY-131914B

EST64454 maleate	Sigma Receptor	Inflammation/Immunology
EST64454 maleate is a highly soluble σ1 receptor antagonist, demonstrating potent antinociceptive properties for pain treatment. EST64454 maleate exhibits excellent metabolic stability across various species and possesses an adequate pharmacokinetic profile in rodents. EST64454 maleate has been identified as a promising clinical candidate due to its favorable aqueous solubility and high permeability in Caco-2 cells.

HY-15007

L 366509	Oxytocin Receptor	Endocrinology
L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists .

HY-W1113139

H2N-PEG4-C3-OH	Biochemical Assay Reagents	Others
H2N-PEG4-C3-OH is a PEG linker with a terminal amino group that can react with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde), etc. Hydroxyl group can react with a variety of functional groups. PEG spacer improves the compound's aqueous solubility.

HY-W591360

Iodoacetamido-PEG6-azide	Biochemical Assay Reagents	Others
Iodoacetamido-PEG6-azide is an aqueous soluble PEG linker containing an azide and a terminal Iodoacetamido group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The Iodoacetamido moiety is commonly used to bind covalently with the thiol group of cysteine so the protein cannot form disulfide bonds.

HY-W800706

Azidobutanamide-tri-(carboxyethoxymethyl)-methane	Biochemical Assay Reagents	Others
Azidobutanamide-tri-(carboxyethoxymethyl)-methane is a aqueous soluble PEG linker with an azide group with three terminal carboxylic acids. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

HY-W800635

4-Azide-TFP-amide-PEG4-acid	Biochemical Assay Reagents	Others
4-Azide-TFP-Amide-PEG4-acid contains an aryl azide and a carboxylic acid with a PEG spacer to increase aqueous solubility and decrease steric hinderance during ligation. The aryl azide can be photo-activated with UV light (250 to 350 nm) for conjugation with biomolecules. Fluoro helps to stabilize the free radical intermediate. The carboxylic acid can be reacted with amines in the presence of an activator to form an amide bond.

HY-179260A

PDLLA3000-mPEG2000, PDI≤1.25	Biochemical Assay Reagents	Others
PDLLA3000-mPEG2000, PDI≤1.25 is an amphiphilic block copolymer composed of methoxy poly(ethylene glycol) and poly(D,L-lactide). PDLLA3000-mPEG2000, PDI≤1.25 functions as a self-assembled polymeric micelle component to enhance aqueous solubility and oral bioavailability in bioactive substances. PDLLA3000-mPEG2000, PDI≤1.25 can be used in the study of drug delivery .

HY-183335

SMO-IN-6	Smo Hedgehog Gli Apoptosis Caspase	Cancer
Anticancer agent 321 is a Smoothened (SMO) inhibitor with a human IC₅₀ of 0.12 μM, enhanced aqueous solubility, good plasma and metabolic stability, moderate therapeutic index, preliminary safety profile, and moderate oral bioavailability in rats.Anticancer agent 321 binds to SMO’s 7-transmembrane helical channel, forming hydrogen bonds with Asp384 and hydrophobic/π-π interactions with His470, Phe391, Tyr394, stabilizing SMO’s inactive conformation to inhibit Hedgehog/GLI signaling.Anticancer agent 321 inhibits proliferation, suppresses colony formation, induces apoptosis, and downregulates Hedgehog/GLI pathway target genes GLI1, GLI2, Ptch1, HHip in cancer cells.Anticancer agent 321 inhibits tumor growth, downregulates Ki67 and SOX2, and upregulates cleaved-caspase 3 in tumor tissues.Anticancer agent 321 can be used for the research of cutaneous squamous cell carcinoma .

Cat. No.	Product Name

HY-L0115V

Asinex Macrocycles Library	10,091 compounds
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks. Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.

Asinex Macrocycles Library

10,091 compounds

ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.

Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.

PDLLA3000-mPEG2000, PDI≤1.25	Biochemical Assay Reagents
PDLLA3000-mPEG2000, PDI≤1.25 is an amphiphilic block copolymer composed of methoxy poly(ethylene glycol) and poly(D,L-lactide). PDLLA3000-mPEG2000, PDI≤1.25 functions as a self-assembled polymeric micelle component to enhance aqueous solubility and oral bioavailability in bioactive substances. PDLLA3000-mPEG2000, PDI≤1.25 can be used in the study of drug delivery .

Cat. No.	Product Name	Target	Research Area