HBV-IN-25
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity.
For research use only. We do not sell to patients.
- CAS No.: 2161364-69-6
- Formula: C18H14ClNO4
- Molecular Weight:343.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.58 μM (anti-HBeAg); 1.15 μM (anti-HBV)[1].
In Vitro
HBV-IN-25 (8-50 μM, 5 days) has anti-HBeAg potency with an IC50 value of 0.58 μM.
HBV-IN-25 (8-50 μM, 5 days) has the anti-HBV activity in PHH is maintained or slightly decreased with IC50 value of 1.15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
Pharmacokinetic Parameters of HBV-IN-25 inHBVcircle mouse model (oral, 5, 20, 100, 300 mg/kg, single)[1].
| Dose | Terminal body weight % versus day 1 | Spinal cord inflammation Foci per 20 cells | Spinal cord demyelination Score 0-5 | Spinal cord apoptotic cells Count per section |
| PK parameter | 5 mg/kg PO | 20 mg/kg PO | 100 mg/kg PO | 300 mg/kg PO |
| Cmax(ng/kg) | 828 | 8157 | 32200 | 59900 |
| Tmax(ng/kg) | 0.25 | 0.5 | 0.5 | 2.67 |
| AUC0 ∞(ng h/mL) | 857 | 11,818 | 119,960 | 453,367 |
| t1/2(h) | 3.46 | 3.45 | 1.82 | |
| dose-normalized Cmax[(ng/mL)/(mg/kg)] | 166 | 408 | 322 | 200 |
| Dose-normalized AUC0 24h [(ng h/mL)/(mg/kg)] | 171 | 591 | 1200 | 1511 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HBVcircle mouse model[1]
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Dosage:5, 20, 100, 300 mg/kg
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Administration:oral, 5, 20, 100, 300 mg/kg, single
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Result:
Chemical Information
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CAS No. 2161364-69-6
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Molecular Weight 343.76
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Formula C18H14ClNO4
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SMILES
O=C([C@H]1CN(C2=CC(OC3=C4C=CC=C3Cl)=C(C=C2)C4=O)CC1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBV-IN-25 Related Classifications
HY-151134 Related Classifications
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