1. Anti-infection
  2. HBV
  3. HBV-IN-25

HBV-IN-25 

Cat. No.: HY-151134
Handling Instructions

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA>452 μg/mL) and good PK property with no cellular toxicity.

For research use only. We do not sell to patients.

HBV-IN-25 Chemical Structure

HBV-IN-25 Chemical Structure

CAS No. : 2161364-69-6

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Description

HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA>452 μg/mL) and good PK property with no cellular toxicity[1].

IC50 & Target

IC50: 0.58 μM (anti-HBeAg); 1.15 μM (anti-HBV)[1].

In Vitro

HBV-IN-25 (8-50 μM, 5 days) has anti-HBeAg potency with an IC50 value of 0.58 μM.
HBV-IN-25 (8-50 μM, 5 days) has the anti-HBV activity in PHH is maintained or slightly decreased with IC50 value of 1.15 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HBV-IN-25 (oral, 5, 20, 100, 300 mg/kg, single) has good PK property, and also shows excellent efficacy in significantly reducing HBV antigens, DNA, and intrahepatic cccDNA levels[1].
Pharmacokinetic Parameters of HBV-IN-25 inHBVcircle mouse model (oral, 5, 20, 100, 300 mg/kg, single)[1].

Dose Terminal body weight % versus day 1 Spinal cord inflammation Foci per 20 cells Spinal cord demyelination Score 0–5 Spinal cord apoptotic cells Count per section
PK parameter 5 mg/kg PO 20 mg/kg PO 100 mg/kg PO 300 mg/kg PO
Cmax(ng/kg) 828 8157 32200 59900
Tmax(ng/kg) 0.25 0.5 0.5 2.67
AUC0−∞(ng h/mL) 857 11,818 119,960 453,367
t1/2(h) 3.46 3.45 1.82
dose-normalized Cmax[(ng/mL)/(mg/kg)] 166 408 322 200
Dose-normalized AUC0−24h [(ng h/mL)/(mg/kg)] 171 591 1200 1511

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HBVcircle mouse model[1]
Dosage: 5, 20, 100, 300 mg/kg
Administration: oral, 5, 20, 100, 300 mg/kg, single
Result:
Molecular Weight

343.76

Formula

C18H14ClNO4

CAS No.
SMILES

O=C([[email protected]]1CN(C2=CC(OC3=C4C=CC=C3Cl)=C(C=C2)C4=O)CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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HBV-IN-25
Cat. No.:
HY-151134
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