HBV-IN-25
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC50 values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity.
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- CAS No.: 2161364-69-6
- Formule: C18H14ClNO4
- Masse moléculaire:343.76
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.58 μM (anti-HBeAg); 1.15 μM (anti-HBV)[1].
HBV-IN-25 (8-50 μM, 5 days) has anti-HBeAg potency with an IC50 value of 0.58 μM.
HBV-IN-25 (8-50 μM, 5 days) has the anti-HBV activity in PHH is maintained or slightly decreased with IC50 value of 1.15 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Parameters of HBV-IN-25 inHBVcircle mouse model (oral, 5, 20, 100, 300 mg/kg, single)[1].
| Dose | Terminal body weight % versus day 1 | Spinal cord inflammation Foci per 20 cells | Spinal cord demyelination Score 0-5 | Spinal cord apoptotic cells Count per section |
| PK parameter | 5 mg/kg PO | 20 mg/kg PO | 100 mg/kg PO | 300 mg/kg PO |
| Cmax(ng/kg) | 828 | 8157 | 32200 | 59900 |
| Tmax(ng/kg) | 0.25 | 0.5 | 0.5 | 2.67 |
| AUC0 ∞(ng h/mL) | 857 | 11,818 | 119,960 | 453,367 |
| t1/2(h) | 3.46 | 3.45 | 1.82 | |
| dose-normalized Cmax[(ng/mL)/(mg/kg)] | 166 | 408 | 322 | 200 |
| Dose-normalized AUC0 24h [(ng h/mL)/(mg/kg)] | 171 | 591 | 1200 | 1511 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HBVcircle mouse model[1]
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Dosage:5, 20, 100, 300 mg/kg
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Administration:oral, 5, 20, 100, 300 mg/kg, single
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Result:
Chemical Information
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CAS No. 2161364-69-6
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Masse moléculaire 343.76
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Formule C18H14ClNO4
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SMILES
O=C([C@H]1CN(C2=CC(OC3=C4C=CC=C3Cl)=C(C=C2)C4=O)CC1)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HBV-IN-25 Related Classifications
HY-151134 Related Classifications
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