Search Result

Results for "

PK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA-PK (40) 5-HT Receptor (3) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (12) ATM/ATR (7) Aurora Kinase (1) Autophagy (6) Bacterial (2) Bcr-Abl (1) Beta-secretase (1) c-Fms (3) c-Kit (1) c-Met/HGFR (1) Casein Kinase (1) CDK (1) Checkpoint Kinase (Chk) (1) COX (1) CRISPR/Cas9 (1) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) EGFR (4) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Factor Xa (1) FAK (1) FGFR (1) FLT3 (4) Fluorescent Dye (1) Fungal (1) GABA Receptor (6) GHSR (1) Glucosylceramide Synthase (GCS) (1) GPR84 (1) GSK-3 (1) HBV (2) HCV Protease (1) Histone Methyltransferase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) IRAK (2) Isotope-Labeled Compounds (1) JNK (1) Keap1-Nrf2 (1) LRRK2 (1) MDM-2/p53 (4) Mitochondrial Metabolism (1) mTOR (15) Parasite (1) PDGFR (3) Phosphodiesterase (PDE) (1) PI3K (16) PKA (2) Potassium Channel (1) Prostaglandin Receptor (1) PROTACs (1) PSMA (1) Pyruvate Kinase (1) Reactive Oxygen Species (1) RIP kinase (1) ROR (1) SARS-CoV (1) Sodium Channel (4) Src (2) TAM Receptor (1) Thrombin (1) Trk Receptor (1) VEGFR (2) γ-secretase (2)
By Research Areas:	Cancer (78) Cardiovascular Disease (3) Endocrinology (2) Infection (11) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (21)

By Targets:

DNA-PK (40)

5-HT Receptor (3)

Amyloid-β (1)

Anaplastic lymphoma kinase (ALK) (1)

Apoptosis (12)

ATM/ATR (7)

Aurora Kinase (1)

Autophagy (6)

Bacterial (2)

Bcr-Abl (1)

Beta-secretase (1)

c-Fms (3)

c-Kit (1)

c-Met/HGFR (1)

Casein Kinase (1)

CDK (1)

Checkpoint Kinase (Chk) (1)

COX (1)

CRISPR/Cas9 (1)

Dipeptidyl Peptidase (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

EGFR (4)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

Factor Xa (1)

FAK (1)

FGFR (1)

FLT3 (4)

Fluorescent Dye (1)

Fungal (1)

GABA Receptor (6)

GHSR (1)

Glucosylceramide Synthase (GCS) (1)

GPR84 (1)

GSK-3 (1)

HBV (2)

HCV Protease (1)

Histone Methyltransferase (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

IRAK (2)

Isotope-Labeled Compounds (1)

JNK (1)

Keap1-Nrf2 (1)

LRRK2 (1)

MDM-2/p53 (4)

Mitochondrial Metabolism (1)

mTOR (15)

Parasite (1)

PDGFR (3)

Phosphodiesterase (PDE) (1)

PI3K (16)

PKA (2)

Potassium Channel (1)

Prostaglandin Receptor (1)

PROTACs (1)

PSMA (1)

Pyruvate Kinase (1)

Reactive Oxygen Species (1)

RIP kinase (1)

ROR (1)

SARS-CoV (1)

Sodium Channel (4)

Src (2)

TAM Receptor (1)

Thrombin (1)

Trk Receptor (1)

VEGFR (2)

γ-secretase (2)

By Research Areas:

Cancer (78)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (12)

Metabolic Disease (5)

Neurological Disease (21)

129

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: DNA-PK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120122

PK7088	Others	Cancer
PK7088 is a pyrazole and a specific peptide. PK7088 supports the reactivation of mutant p53 by converting it to a form exhibiting wild-type properties. PK7088 exhibit anticancer activity in cancer research .

HY-153767

PK095

MDM-2/p53 Cancer

PK095 is a p53 mutant stabilizer. PK095 can be used for research of cancer .

PK095	MDM-2/p53	Cancer
PK095 is a p53 mutant stabilizer. PK095 can be used for research of cancer .

HY-P2806

Pyruvate Kinase, Microorganism PK; Fluorokinase	Endogenous Metabolite	Metabolic Disease
Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP .

HY-100140A

Pipequaline hydrochloride PK-8165 hydrochloride	GABA Receptor	Neurological Disease
Pipequaline hydrochloride (PK-8165 hydrochloride) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-156090

PK-10	Mitochondrial Metabolism Fungal	Infection
PK-10 is a synergistic antibacterial agent of Fluconazole (HY-B0101) and has strong antifungal activity against a variety of Fluconazole-resistant Candida albicans strains. PK-10 combined with Fluconazole can inhibit hyphae formation and induce the accumulation of reactive oxygen species. It further causes damage to mitochondrial membrane potential, reduces intracellular ATP content, and leads to mitochondrial dysfunction .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-U00447

PK11000	MDM-2/p53 DNA Alkylator/Crosslinker	Cancer
PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities .

HY-100346

PK14105

Others Others

PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.
HY-145937

PK9327

MDM-2/p53 Cancer

PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

PK14105	Others	Others
PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.

PK9327	MDM-2/p53	Cancer
PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.

HY-110184

PK-THPP	Potassium Channel	Neurological Disease
PK-THPP is a potent TWIK-related acid-sensitive K(+) ion channel (TASK-3 ion channel) blocker (IC₅₀s are 35 nM and 300 nM for TASK-3 and TASK-1, respectively) . PK-THPP increases breathing rate and induces respiratory alkalosis in rats .

HY-110083

PK44 phosphate

Dipeptidyl Peptidase Metabolic Disease

PK44 phosphate is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM .

PK44 phosphate	Dipeptidyl Peptidase	Metabolic Disease
PK44 phosphate is a potent dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ value of 15.8 nM .

HY-128348

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

HY-100140

Pipequaline

PK-8165
GABA Receptor Neurological Disease

Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity .

Pipequaline PK-8165	GABA Receptor	Neurological Disease
Pipequaline (PK 8165) is a partial benzodiazepine receptor agonist with anxiolytic activity .

HY-133119

PK150	Bacterial	Infection
PK150, an analogue of Sorafenib, shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations. PK150 inhibits Gram-positive Methicillin-sensitive S. aureus (MSSA), Methicillin-resistant S. aureus (MRSA), Vancomycin intermediate S. aureus (VISA) with MICs of 0.3, 0.3-1, 0.3 µM, respectively .

HY-19567

PK 11195 1 Publications Verification RP 52028
PK 11195 (RP 52028) is a ligand of translocator protein (TSPO), which targets Leishmania chemotherapy, with IC₅₀s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis, L. major and L. braziliensis, respectively.

HY-109509

Enoxaparin PK 10169; Enoxaparin sodium; Lovenox	Factor Xa Thrombin SARS-CoV	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .

HY-117389

Homocarbonyltopsentin PK4C9	Others	Others
Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC₅₀ value of 16 μM .

HY-B0211

Riluzole 5+ Cited Publications PK 26124	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0211A

Riluzole hydrochloride 5+ Cited Publications PK 26124 hydrochloride	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-B0211R

Riluzole (Standard) PK 26124 (Standard)	Sodium Channel GABA Receptor	Neurological Disease Cancer
Riluzole (Standard) is the analytical standard of Riluzole. This product is intended for research and analytical applications. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na ⁺ channel blocker which can also inhibit GABA uptake with an IC₅₀ of 43 μM.

HY-P10047

PKItide

PKA Others

PKItide exhibits an IC₅₀ of 0.2 μM for cAMP-PK .

PKItide	PKA	Others
PKItide exhibits an IC₅₀ of 0.2 μM for cAMP-PK .

HY-109190

Seralutinib 1 Publications Verification GB002; PK10571	PDGFR c-Fms c-Kit	Cardiovascular Disease
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC₅₀s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension .

HY-147056

PKRA83 PKRA7	Others	Inflammation/Immunology Cancer
PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC₅₀ values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. PKRA83 can penetrate the blood-brain barrier .

HY-B0211S

Riluzole-13C,15N2 PK 26124-¹³C,¹⁵N₂	GABA Receptor Sodium Channel
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

HY-153943

DNA-PK-IN-10

DNA-PK Cancer

DNA-PK-IN-10 is a DNA-PK inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer .

DNA-PK-IN-10	DNA-PK	Cancer
DNA-PK-IN-10 is a *DNA-PK* inhibitor. DNA-PK-IN-10 can be used for the research of breast cancer and non-small cell lung cancer .

HY-144036

DNA-PK-IN-3	DNA-PK	Cancer
DNA-PK-IN-3 is a potent inhibitor of *DNA-PK*. DNA-PK-IN-3 synergistically enhances the effect of radiotherapy and chemotherapy and effectively inhibits tumor growth. DNA-PK-IN-3 also effectively reduces the damage to normal cells and reducing side effects. DNA-PK-IN-3 has the potential for the research of cancer disease (extracted from patent WO2021213460A1, compound 4) .

HY-144037

DNA-PK-IN-4	DNA-PK	Cancer
DNA-PK-IN-4 is a potent inhibitor of *DNA-PK*. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) .

HY-142943

DNA-PK-IN-1	DNA-PK	Cancer
DNA-PK-IN-1 is a potent inhibitor of *DNA-PK*. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-1 has the potential for the research of cancer diseases (extracted from patent WO2021136463A1, compound 1) .

HY-142944

DNA-PK-IN-2	DNA-PK	Cancer
DNA-PK-IN-2 is a potent inhibitor of *DNA-PK*. DNA-dependent protein kinase (DNA-PK) is a DNA-PK enzyme complex composed of Ku70/Ku80 heterodimer and DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK-IN-2 has the potential for the research of cancer diseases (extracted from patent WO2021136462A1, compound 1) .

HY-146566

DNA-PK-IN-9	DNA-PK	Cancer
DNA-PK-IN-9 (compound YK6) is a potent DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of 10.47 nM. DNA-PK-IN-9 can be used for researching anticancer .

HY-160096

DNA-PK-IN-11

DNA-PK Cancer

DNA-PK-IN-11 is a DNA-PK inhibitor with an IC₅₀ of <0.1 μM (DE102010035744A1; compound 36) .

DNA-PK-IN-11	DNA-PK	Cancer
DNA-PK-IN-11 is a *DNA-PK* inhibitor with an IC₅₀ of <0.1 μM (DE102010035744A1; compound 36) .

HY-163134

DNA-PK-IN-12	DNA-PK	Cancer
DNA-PK-IN-12 (compound 31t) is an oral active *DNA-PK* inhibitor with the IC₅₀ of 0.1 nM. DNA-PK-IN-12 inhibits cell growth and Hct116 cell colony formation with the IC₅₀ of 33.28 μM, and shows antitumor activity in vivo .

HY-144039

DNA-PK-IN-6	DNA-PK	Cancer
DNA-PK-IN-6 is a potent inhibitor of *DNA-PK*. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6) .

HY-144038

DNA-PK-IN-5	DNA-PK	Cancer
DNA-PK-IN-5 is a potent inhibitor of *DNA-PK*. DNA-PK-IN-5 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-5 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021204111A1, compound 2) .

HY-146565

DNA-PK-IN-8	DNA-PK	Cancer
DNA-PK-IN-8 is a highly potent, selective and orally active DNA-dependent protein kinase (DNA-PK) inhibitor with an IC₅₀ value of 0.8 nM. DNA-PK-IN-8 exhibits synergistic antiproliferative activity against a series of cancer cell lines and significantly suppresses HL-60 tumor growth, when using in combination with Doxorubicin .

HY-162332

EGFR-PK/JNK-2-IN-1	Apoptosis EGFR JNK	Cancer
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of *EGFR-PK* and JNK-2 with IC₅₀s of 2.7 and 3.0 μM, respectively. EGFR-PK/JNK-2-IN-1 can induce apoptosis and induce cell cycle arrest at different cell phases. EGFR-PK/JNK-2-IN-1 can be used for the research of cancer .

HY-157928

Keap1-Nrf2-IN-18	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-18 (Compound 22) is an orally active Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with good pharmacokinetics (PK) profiles and more potent in vivo activities in rats. Keap1-Nrf2-IN-18 has the strongest inhibitory activity in structure−activity relationship (SAR) study (K_D = 0.0029 μM) .

HY-151134

HBV-IN-25	HBV	Infection
HBV-IN-25 is a good potency, orally active novel HBV cccDNA reducer. HBV-IN-25 has anti-HBeAg potency and anti-HBV activity with IC₅₀ values of 0.58 μM and 1.15 μM, respectively. HBV-IN-25 has good aqueous solubility (LYSA＞452 μg/mL) and good PK property with no cellular toxicity .

HY-12030

PIK-90

2 Publications Verification

PI3K DNA-PK Cancer

PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC₅₀s of 11, 18 and 13 nM, respectively.

PIK-90 2 Publications Verification	PI3K DNA-PK	Cancer
PIK-90 is a *DNA-PK* and PI3K inhibitor, which inhibits p110α, p110γ and *DNA-PK* with IC₅₀s of 11, 18 and 13 nM, respectively.

HY-123637

Autotaxin-IN-1	Phosphodiesterase (PDE)	Inflammation/Immunology
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC₅₀=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain .

HY-147262

Etedesiran

Others Others

Etedesiran is a Myotonin-protein kinase (MT-PK, MDPK, or DMPK) inhibitor .

Etedesiran	Others	Others
Etedesiran is a Myotonin-protein kinase (MT-PK, MDPK, or DMPK) inhibitor .

HY-101667

LTURM34 4 Publications Verification	DNA-PK	Cancer
LTURM34 is a specific *DNA-PK* inhibitor (IC₅₀=34 nM). LTURM34 exhibits 170-fold selectivity for DNA-PK over PI3K. LTURM34 shows potent antiproliferative activity in a wide range of tumor cell lines .

HY-100706

AMA-37
AMA-37, an Arylmorpholine analog, is ATP-competitive *DNA-PK* inhibitor, with IC₅₀ values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively .

HY-136219

Protein kinase affinity probe 1	Others	Others
Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3) .

HY-12689

Mitapivat AG-348	Pyruvate Kinase	Metabolic Disease
Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency .

HY-19939S2

(R)-VX-984

(R)-M9831
DNA-PK Others

(R)-VX-984 is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.
HY-142471A

ZL-2201

DNA-PK Cancer

ZL-2201 is a potent DNA-PK inhibitor with an IC₅₀ of 1 nM (WO2021104277A1, compound 5) .

(R)-VX-984 (R)-M9831	DNA-PK	Others
(R)-VX-984 is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.

HY-13431

KU-0060648 1 Publications Verification	DNA-PK PI3K mTOR	Cancer
KU-0060648 is a dual inhibitor of PI3K and *DNA-PK* with IC₅₀s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .

HY-151575

PfGSK3/PfPK6-IN-2	GSK-3	Infection
PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC₅₀: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria .

HY-142471

ZL-2201 free base

DNA-PK Cancer

ZL-2201 free base is a potent DNA-PK inhibitor with an IC₅₀ of 1 nM (WO2021104277A1, compound 5) .

Cat. No.	Product Name

HY-L015

PI3K/Akt/mTOR Compound Library

568 compounds

The PI3K/Akt/mTOR pathway controls many cellular processes that are important for the formation and progression of cancer, including apoptosis, transcription, translation, metabolism, angiogenesis, and cell cycle progression. Every major node of this signaling network is activated in a wide range of human tumors. Mechanisms for the pathway activation include activation of receptor tyrosine kinases (RTKs) upstream of PI3K, mutation or amplification of PIK3CA encoding p110α catalytic subunit of PI3K, mutation or loss of PTEN tumor suppressor gene, and mutation or amplification of Akt1. Once the pathway is activated, signaling through Akt can stimulate a series of substrates including mTOR which is involved in protein synthesis. Thus, inhibition of this pathway is an attractive concept for cancer prevention and/or therapy. Currently some mTOR inhibitors are approved for several indications, and there are several novel PI3K/Akt/mTOR inhibitors in clinical trials.

MCE owns a unique collection of 568 compounds that can be used for PI3K/Akt/mTOR pathway research. PI3K/Akt/mTOR Compound Library also acts as a useful tool for anti-cancer drug discovery.

HY-L004

Cell Cycle/DNA Damage Compound Library

2001 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 2001 cell cycle/DNA damage-related compounds which can be used in the research of the same.

HY-L041

Macrocyclic Compound Library

364 compounds

Macrocycles, molecules containing 12-membered or larger rings, are receiving increased attention in small-molecule drug discovery. The reasons are several, including providing access to novel chemical space, challenging new protein targets, showing favorable ADME- and PK-properties. Macrocycles have demonstrated repeated success when addressing targets that have proved to be highly challenging for standard small-molecule drug discovery, especially in modulating macromolecular processes such as protein–protein interactions (PPI). Otherwise, the size and complexity of macrocyclic compounds make possible to ensure numerous and spatially distributed binding interactions, thereby increasing both binding affinity and selectivity.

MCE offers a unique collection of 364 macrocyclic compounds which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE Macrocyclic Compound Library is a useful tool for discovering new drugs, especially for “undruggable” targets and protein–protein interactions.

Cat. No.	Product Name	Target	Research Area

HY-P10047

PKItide

PKA Others

PKItide exhibits an IC₅₀ of 0.2 μM for cAMP-PK .
HY-126809

Chromozym PK

Peptides Others

Chromozym PK is a Chromogenic Substrate and can be used in? Factor XII assay .

HY-P5429

DNA-PK Substrate	Peptides	Others
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P3907

Kemptide (amide)	Peptides	Others
Kemptide (amide) is a heptapeptide with properties of a cytophilic substrate. Kemptide is a molecule preserving cell membrane intactness, is phosphorylated by PKI, the inhibitory protein specific for cAMP-dependent protein kinase (PK) .

HY-P10034

Pheromonotropin (pseudaletia separata) Pss-PT	Peptides	Endocrinology
Pheromonotropin (Pseudaletia separata) (Pss-PT) is an armyworm (Pseudaletia separata) pheromone with the C-terminal pentapeptide FXPRL-amide. Pheromonotropin (Pseudaletia separata) belongs to the PK/PBAN family and stimulates sex pheromone biosynthesis in moths, mediating feeding (intestinal muscle contraction), development (embryonic diapause, pupal diapause, and pupation), and defense against natural enemy insects wait .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122379

8-Hydroxypinoresinol	Structural Classification Oleaceae Source classification Lignans Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl	Others
8-Hydroxypinoresinol is a tetrahydrofurofuran lignan that has cytoprotective effects against peroxynitrite-induced LLC-PK1 cell damage .

HY-N2757

7-Ketositosterol	Structural Classification Natural Products Source classification Plants Moraceae Morus alba Linn.	Apoptosis
7-Ketositosterol is a phytosterol isolated from the fruits of the mulberry tree (Morus alba L.). 7-Ketositosterol can significantly inhibit Cisplatin (HY-17394)-induced apoptosis in LLC-PK1 cells and has the potential to improve Cisplatin-induced nephrotoxicity .

Species:	Human (12) Mouse (1) Rat (1)
Tag:	His (8) Tag Free (2) Myc (1) GST (5)
Source:	HEK293 (2) Sf9 insect cells (9) P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74421

	AKT1 Protein, Human (sf9, His) 2 Publications Verification RAC-alpha serine/threonine-protein kinase; PKB; RAC-PK-alpha; AKT1; RAC	Human	Sf9 insect cells
	AKT1 Protein, part of the AKT kinase family, crucially regulates metabolism, proliferation, survival, growth, and angiogenesis. Phosphorylating over 100 substrates, it orchestrates insulin-induced SLC2A4/GLUT4 translocation, impacting glucose uptake, and governs glycogen storage by inhibiting GSK3A/B. AKT1 mediates insulin-stimulated protein synthesis via mTORC1, regulates FOXO factors, influences NF-kappa-B-dependent gene transcription, and enhances CREB1 activity. It modulates lipid metabolism, inhibiting lipolysis, and is involved in cell migration, adhesion, placental development, and responses to growth factors like PDGF, EGF, insulin, and IGF-I. Its role in SPATA13-mediated regulation adds complexity, highlighting AKT1's central role in cellular homeostasis and responsiveness to cues. AKT1 Protein, Human (sf9, His) is the recombinant human-derived AKT1 protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of AKT1 Protein, Human (sf9, His) is 480 a.a., with molecular weight of ~57 kDa.

HY-P72053

	PKM2 Protein, Mouse (Baculovirus, His-Myc) PKm; PK3; PKm2; PykmPyruvate kinase PKM; EC 2.7.1.40; Pyruvate kinase muscle isozyme	Mouse	Sf9 insect cells
	PKM2 protein catalyzes the final step of glycolysis, transferring a phosphoryl group from PEP to ADP to generate ATP. In the nucleus, transcriptional activation of PKM2 contributes to cancer progression, promoting cell proliferation and tumorigenesis. PKM2 is also involved in caspase-independent cell death in tumors. PKM2 Protein, Mouse (Baculovirus, His-Myc) is the recombinant mouse-derived PKM2 protein, expressed by Sf9 insect cells , with N-10*His, C-Myc labeled tag. The total length of PKM2 Protein, Mouse (Baculovirus, His-Myc) is 531 a.a., with molecular weight of ~61.8 kDa.

HY-P71210

	PKLR Protein, Human (HEK293, His) Pyruvate Kinase Isozymes R/L; Pyruvate Kinase 1; R-Type/L-Type Pyruvate Kinase; Red Cell/Liver Pyruvate Kinase; PKLR; PK1; PKL	Human	HEK293
	The PKLR protein is a key enzyme in cellular metabolism that acts as a pyruvate kinase, converting phosphoenolpyruvate to pyruvate. This process is an integral part of glycolysis, the fundamental pathway for cellular energy production. PKLR Protein, Human (HEK293, His) is the recombinant human-derived PKLR protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PKLR Protein, Human (HEK293, His) is 574 a.a., with molecular weight of ~62.0 kDa.

HY-P702631

	AKT1 Protein, Human (Active, sf9, GST) AKT1; v-akt murine thymoma viral oncogene homolog 1; RAC-alpha serine/threonine-protein kinase; AKT; PKB; PRKBA; RAC; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha; PKB-ALPHA; RAC-ALPHA; MGC99656	Human	Sf9 insect cells

HY-P700578

	PKLR Protein, Rat (P. pastoris, His) PKLR; pyruvate kinase, liver and RBC; PK1; PKL; PKR; RPK; PKRL; pyruvate kinase isozymes R/L; pyruvate kinase 1; OTTHUMP00000034069; pyruvate kinase type L; pyruvate kinase isozyme R/L; R-type/L-type pyruvate kinase; red cell/liver pyruvate kinase; pyruvate kinase, liver and blood cell; EC 2.7.1.40	Rat	P. pastoris
	PKLR Protein, a pyruvate kinase, plays a crucial role in glycolysis, converting phosphoenolpyruvate to pyruvate and generating ATP. As a key enzyme, PKLR mediates the final steps of glycolysis, contributing to energy production. Its catalytic activity influences pyruvate, a central metabolite with implications for cellular processes, including energy metabolism and the tricarboxylic acid (TCA) cycle. PKLR's significance in glycolytic flux underscores its essential role in cellular energy homeostasis, presenting potential for therapeutic interventions in metabolic pathways. PKLR Protein, Rat (P. pastoris, His) is the recombinant rat-derived PKLR protein, expressed by P. pastoris, with N-6*His labeled tag. The total length of PKLR Protein, Rat (P. pastoris, His) is 574 a.a., with molecular weight of 64.2 kDa.

HY-P701752

	PK3C3 Protein, Human (Sf9, His, GST) PIK3C3; Phosphatidylinositol 3-kinase catalytic subunit type 3; PI3-kinase type 3; PI3K type 3; PtdIns-3-kinase type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34	Human	Sf9 insect cells
	The PI3KC3 protein is the catalytic subunit of the PI3K complex and mediates the formation of phosphatidylinositol 3-phosphate. PI3KC3-C1 initiates autophagosomes, whereas PI3KC3-C2 promotes autophagosome maturation and endocytosis. PK3C3 Protein, Human (Sf9, His, GST) is the recombinant human-derived PK3C3 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of PK3C3 Protein, Human (Sf9, His, GST) is 886 a.a., .

HY-P702632

	AKT2 Protein, Human (Active, sf9, GST) AKT2; v-akt murine thymoma viral oncogene homolog 2; PKBB; PRKBB; PKBBETA; RAC-BETA; AKT2 kinase; rac protein kinase beta; Murine thymoma viral (v-akt) homolog-2; EC 2.7.11.1; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; PKB beta	Human	Sf9 insect cells

HY-P702633

	AKT3 Protein, Human (Active, sf9, GST) AKT3; AKT serine/threonine kinase 3; MPPH; PKBG; MPPH2; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; RAC-gamma serine/threonine-protein kinase; PKB gamma; RAC-gamma serine/threonine protein kinase; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); EC 2.7.11.1	Human	Sf9 insect cells

HY-P701665

	DMPK Protein, Human (Sf9) DMPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase	Human	Sf9 insect cells
	DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with tag free. The total length of DMPK Protein, Human (Sf9) is 629 a.a., .

HY-P701666

	DMPK Protein, Human (Sf9, His) DMPK; Myotonin-protein kinase; MT-PK; DM-kinase; DMK; DM1 protein kinase; DMPK; Myotonic dystrophy protein kinase	Human	Sf9 insect cells
	DMPK is a non-receptor serine/threonine protein kinase that is critical for skeletal muscle integrity, affecting myocyte differentiation, nuclear membrane integrity, and muscle-specific gene expression. It may inhibit myosin phosphatase (PPP1R12A), regulate myosin phosphorylation and affect cardiac contractility and conduction. DMPK Protein, Human (Sf9, His) is the recombinant human-derived DMPK protein, expressed by Sf9 insect cells , with N-6*His labeled tag. The total length of DMPK Protein, Human (Sf9, His) is 629 a.a., .

HY-P702663

	MAPKAPK3 Protein, Human (Active, sf9, GST) MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3; MAP kinase-activated protein kinase 3; 3PK; 3PK; MAPKAP3; MAPKAP kinase 3; chromosome 3p kinase; MAPK-activated protein kinase 3; MK-3; MAPKAP-K3; MAPKAPK-3	Human	Sf9 insect cells

HY-P701810

	MELK Protein, Human MELK; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK	Human	E. coli
	MELK is a multifunctional serine/threonine protein kinase that regulates the cell cycle, stem cell self-renewal, apoptosis, and splicing. MELK phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622, activates apoptosis through MAP3K5/ASK1, helps CDC25B localize during mitosis, and inhibits BCL2L14, which may affect breast cancer occurrence. MELK Protein, Human is the recombinant human-derived MELK protein, expressed by E. coli , with tag free. The total length of MELK Protein, Human is 328 a.a., .

HY-P701811

	MELK Protein, Human (His) MELK; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK	Human	E. coli
	MELK is a multifunctional serine/threonine protein kinase that regulates the cell cycle, stem cell self-renewal, apoptosis, and splicing. MELK phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622, activates apoptosis through MAP3K5/ASK1, helps CDC25B localize during mitosis, and inhibits BCL2L14, which may affect breast cancer occurrence. MELK Protein, Human (His) is the recombinant human-derived MELK protein, expressed by E. coli , with N-6*His labeled tag. The total length of MELK Protein, Human (His) is 328 a.a., .

HY-P71118

	PFKFB1 Protein, Human (HEK293, His) 6-phosphofructo-2-kinase/fructose-2; 6-bisphosphatase 1; 6PF-2-K/Fru-2; 6-P2ase liver isozyme; Fructose-2; 6-bisphosphatase; PFKFB1; F6PK; PFRX	Human	HEK293
	PFKFB1 protein orchestrates the synthesis and degradation of fructose 2,6-bisphosphate, regulating cellular energy metabolism. Serving as a key enzyme, PFKFB1 modulates fructose 2,6-bisphosphate levels, impacting glycolysis and gluconeogenesis. Its dual role in both synthesis and breakdown is crucial for maintaining cellular energy homeostasis, ensuring adaptability to changing energy demands and environmental conditions. PFKFB1 Protein, Human (HEK293, His) is the recombinant human-derived PFKFB1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PFKFB1 Protein, Human (HEK293, His) is 470 a.a., with molecular weight of ~60.0 kDa.

Cat. No.	Product Name	Chemical Structure

HY-19939S2

(R)-VX-984

(R)-VX-984 is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.

HY-19939S

VX-984 4 Publications Verification
VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium .

HY-B0211S

Riluzole-13C,15N2
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80870

PKM2 Antibody PKM; OIP3; PK2; PK3; PKM2; Pyruvate kinase isozymes M1/M2; Cytosolic thyroid hormone-binding protein; CTHBP; Opa-interacting protein 3; OIP-3; Pyruvate kinase 2/3; Pyruvate kinase muscle isozyme; Thyroid hormone-binding protein 1; THBP1; Tu	WB	Human, Mouse, Rat, Monkey
PKM2 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 58 kDa, targeting to PKM2. It can be used for WB assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P83643

Phospho-PKM2(Tyr148)Antibody PKM2 (Phospho Tyr148); PKM2 (Phospho Y148); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; PK3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3; KPYM_HUMAN.	WB, IHC-P, IHC-F, ICC, IF, Flow-Cyt, ELISA	Human (predicted: Mouse, Rat, Pig, Cow, Rabbit, Sheep, GuineaPig)

HY-P83644

Phospho-PKM2(Tyr105)Antibody PKM2 (Phospho Tyr105); PKM2 (Phospho Y105); PK 1; PK 2; PK 3; PK Muscle type; PK1; PK2; PK3; PKL; PKLR; PKM 2; PKM; PYKM; Pyruvate kinase 1; Pyruvate kinase 2/3; Pyruvate kinase 3; Pyruvate kinase isozyme R/L; Pyruvate kinase isozymes M1/M2; Pyruvate kinase liver and blood cell; Pyruvate kinase liver and RBC; Pyruvate kinase liver and RBC type; Pyruvate kinase M2; Pyruvate kinase muscle; Pyruvate kinase muscle isozyme; Pyruvate kinase type L; R type/L type pyruvate kinase; Red cell/liver pyruvate kinase; RPK; TCB; THBP 1; THBP1; Thyroid hormone binding protein cytosolic; CTHBP; Cytosolic thyroid hormone binding protein; MGC3932; OIP 3; Oip3; Tumor M2-PK; p58; OIP-3.	IHC-P, IHC-F, IF, Flow-Cyt, ELISA	Human, Rat (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, GuineaPig)

HY-P83246

EG VEGF Antibody (YA2991)

EGVEGF; Mambakine; PK1; PRK1; PROK1; Prokineticin-1
WB, FC Human, Mouse

HY-P80789

Phospho-AKT (Thr308) Antibody AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
Phospho-AKT (Thr308) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 56 kDa, targeting to Phospho-AKT (Thr308). It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80788

Phospho-AKT1 (Ser473) Antibody AKT1; PKB; RAC; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha	WB	Human, Mouse, Rat
Phospho-AKT1 (Ser473) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to Phospho-AKT (Ser473). It can be used for WB assays with tag free, in the background of Human, Mouse, Rat.

HY-P80276

Phospho-AKT1(Ser473) Antibody AKT 1 antibody; AKT antibody; AKT1 antibody; AKT1_HUMAN antibody; MGC99656 antibody; PKB antibody; PKB-ALPHA antibody; PRKBA antibody; Protein Kinase B Alpha antibody; Protein kinase B antibody; Proto-oncogene c-Akt antibody; RAC Alpha antibody; RAC antibody; RAC-alpha serine/threonine-protein kinase antibody; RAC-PK-alpha antibody;	WB, ICC/IF, IHC-P	Human, Mouse
Phospho-Akt1(Ser473) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 56 kDa, targeting to Phospho-Akt1(Ser473). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

HY-P81162

PIK3CA Antibody PI3 kinase p110 subunit alpha; caPI3K; MGC142161; MGC142163; p110 alpha; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; Phosphatidylinositol 3 kinase catalytic 110 KD alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform; Phosphoinositide 3 kinase catalytic alpha polypeptide; PI3 kinase p110 subunit alpha; PI3K; PI3KC A; PIK3C A; PK3CA; PtdIns 3 kinase p110; PI3-kinase P110α; PI3-kinase p110 subunit alpha; PI 3 Kinase catalytic subunit alpha; PK3CA_HUMAN; PI3 kinase P110α.	WB; ELISA; IHC-P; IHC-F; ICC; IF	Human, Mouse, Rat(predicted: Chicken, Cow, Rabbit)
PIK3CA Antibody is an unconjugated, approximately 117 kDa, rabbit-derived, anti-PIK3CA polyclonal antibody. PIK3CA Antibody can be used for: WB, ELISA, IHC-P, IHC-F, ICC, IF expriments in human, mouse, rat, and predicted: chicken, cow, rabbit background without labeling.

HY-P81199

phospho-PI3KCA (Tyr317) Antibody PIK3CA(phospho Y317); PI3 kinase p110 subunit alpha; caPI3K; MGC142161; MGC142163; p110 alpha; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; Phosphatidylinositol 3 kinase catalytic 110 KD alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform; Phosphoinositide 3 kinase catalytic alpha polypeptide; PI3 kinase p110 subunit alpha; PI3K; PI3KC A; PIK3C A; PIK3CA; PK3CA; PtdIns 3 kinase p110; PI3-kinase P110α; PI3-kinase p110 subunit alpha; PI 3 Kinase catalytic subunit alpha; PK3CA_HUMAN; PI3 kinase P110α.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat)
phospho-PI3KCA (Tyr317) Antibody is an unconjugated, approximately 117 kDa, rabbit-derived, anti-phospho-PI3KCA (Tyr317) polyclonal antibody. phospho-PI3KCA (Tyr317) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat background without labeling.

HY-P80445

CaMKII alpha Antibody 1 Publications Verification Alpha CaMKII; Calcium calmodulin dependent protein kinase II; Calcium/calmodulin dependent protein kinase II alpha B subunit; Calcium/calmodulin dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; Calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase II-alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type IIA; CaM kinase II alpha chain; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMK II alpha subunit; CaMK-II subunit alpha; Camk2a; CAMKA; CaMKII; CaMKIINalpha; EC2.7.11.17; KCC2A_HUMAN; KIAA0968; MGC123320; MGC139375; MGC155201; mKIAA0968; PK2CDD; PKCCD; R74975; zgc:112538; zgc:123320;	WB, IP, FC, IHC-P	Human, Mouse, Rat
CaMKII alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 54 kDa, targeting to CaMKII alpha. It can be used for WB,IP,FC,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P81229

PI3 Kinase p110 beta Antibody PI3-kinase p110 subunit beta; p110 BETA; p110Beta; PI3K beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; ICC; IF	Human, Mouse, Rat(predicted: Dog, Cow, Horse, Rabbit)
PI3 Kinase p110 beta Antibody is an unconjugated, approximately 123 kDa, rabbit-derived, anti-PI3 Kinase p110 beta polyclonal antibody. PI3 Kinase p110 beta Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, ICC, IF expriments in human, mouse, rat, and predicted: dog, cow, horse, rabbit background without labeling.

HY-P81211

phospho-PI3 Kinase p110 beta (Ser1070) Antibody PI3-kinase p110 subunit beta; p-PI3Kβ(Ser1070); PI 3-kinase C2β; p110 BETA; p110Beta; Phosphatidylinositol 3 kinase catalytic beta polypeptide; Phosphatidylinositol 4 5 bisphosphate 3 kinase 110 kDa catalytic subunit beta; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit beta isoform; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic beta polypeptide; PI3 kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K beta; PI3K-beta; PI3Kbeta; PI3KCB; PIK3C1; Pik3cb; PK3CB_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit beta; PtdIns-3-kinase subunit p110-beta; 5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; 5-bisphosphate 3-kinase catalytic subunit beta isoform.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow, Horse, Guinea Pig)
phospho-PI3 Kinase p110 beta (Ser1070) Antibody is an unconjugated, approximately 110-123 kDa, rabbit-derived, anti-phospho-PI3 Kinase p110 beta (Ser1070) polyclonal antibody. phospho-PI3 Kinase p110 beta (Ser1070) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, guinea pig background without labeling.

HY-P81270

DNA PKcs Antibody (YA957)

PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P81270A

DNA PKcs Antibody (YA958)

PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
WB, ICC/IF, IP Human
HY-P81270B

DNA PKcs Antibody (YA959)

PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P82078

Phospho-DNA PKcs (Ser2056) Antibody (YA1823)

PRKDC; HYRC; HYRC1; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; DNA-PKcs; DNPK1; p460
WB, IHC-P, ICC/IF Human
HY-P81678

MELK Antibody (YA1423)

MELK; KIAA0175; Maternal embryonic leucine zipper kinase; hMELK; Protein kinase Eg3; pEg3 kinase; Protein kinase PK38; hPK38; Tyrosine-protein kinase MELK
WB Human

HY-P83325

MAPKAP Kinase 3 Antibody (YA3070) MAPKAPK3; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; MK-3; Chromosome 3p kinase; 3PK	WB, IP	Human

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