2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. TC-A 2317 hydrochloride

TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity.

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TC-A 2317 hydrochloride Chemical Structure

TC-A 2317 hydrochloride Chemical Structure

CAS No. : 1245907-03-2

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TC-A 2317 hydrochloride Related Antibodies

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Description

TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1].

IC50 & Target[1]

Aurora A

1.2 nM (Ki)

Aurora B

101 nM (Ki)

In Vitro

TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC-A 2317 hydrochloride Related Antibodies
In Vivo

TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight[1].
TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 Xenograft mice mode[1]
Dosage: P.o.; daily for 14 days
Administration: 30 mg/kg
Result: Growth of tumor was inhibited by 59% after 14 days.
Molecular Weight

392.93

Formula

C19H29ClN6O
CAS No.
SMILES

N#CC1=C(C)C=C(NC2=NNC(C)=C2)N=C1NC(C)CCCC(C)(O)C.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TC-A 2317 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-A 23171245907-03-2Aurora KinaseproliferationantitumorHCT-116oralpermeabilityselectiveInhibitorinhibitorinhibit

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