1. Cell Cycle/DNA Damage
    Epigenetics
  2. Aurora Kinase
  3. TC-A 2317 hydrochloride

TC-A 2317 hydrochloride 

Cat. No.: HY-103266
Handling Instructions

TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity.

For research use only. We do not sell to patients.

TC-A 2317 hydrochloride Chemical Structure

TC-A 2317 hydrochloride Chemical Structure

CAS No. : 1245907-03-2

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Description

TC-A 2317 hydrochloride is an orally active Aurora A kinase inhibitor (Ki=1.2 nM). TC-A 2317 hydrochloride exhibits excellent selectivity to Aurora B kinase (Ki=101 nM) and other 60 kinases, good cell permeability and good PK profile. Antitumor activity[1].

IC50 & Target[1]

Aurora A

1.2 nM (Ki)

Aurora B

101 nM (Ki)

In Vitro

TC-A 2317 hydrochloride (Compound 6) inhibits proliferation of HCT116 cells with an IC50 of 115 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TC-A 2317 hydrochloride is effective in antitumor mice model without decrease of body weight[1].
TC-A 2317 hydrochloride shows good PK profile; Cmax value is 4930 nM (Tmax=1.2 h) and serum concentration after 24 h is 52 nM (T1/2=3.3 h) at 30 mg/kg po in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCT-116 Xenograft mice mode[1]
Dosage: P.o.; daily for 14 days
Administration: 30 mg/kg
Result: Growth of tumor was inhibited by 59% after 14 days.
Molecular Weight

392.93

Formula

C₁₉H₂₉ClN₆O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TC-A 2317 hydrochloride
Cat. No.:
HY-103266
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