2. Anti-infection
  3. Bacterial
  4. Tuberculosis inhibitor 3

Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability.

For research use only. We do not sell to patients.

Tuberculosis inhibitor 3 Chemical Structure

Tuberculosis inhibitor 3 Chemical Structure

CAS No. : 2219325-28-5

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

Tuberculosis inhibitor 3 Related Antibodies

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Description

Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against agent-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].

In Vitro

Tuberculosis inhibitor 3 (compound 2i, 50 mg/kg) shows acceptable PK properties with the AUC of 2489 h•ng/mL) is. The Tmax of Tuberculosis inhibitor 3 is 0.25 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tuberculosis inhibitor 3 Related Antibodies
Molecular Weight

524.48

Formula

C21H22F6N4O3S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCC(CN4CCC(C(F)(F)F)CC4)CC3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 27.5 mg/mL (52.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9067 mL 9.5333 mL 19.0665 mL
5 mM 0.3813 mL 1.9067 mL 3.8133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9067 mL 9.5333 mL 19.0665 mL 47.6663 mL
5 mM 0.3813 mL 1.9067 mL 3.8133 mL 9.5333 mL
10 mM 0.1907 mL 0.9533 mL 1.9067 mL 4.7666 mL
15 mM 0.1271 mL 0.6356 mL 1.2711 mL 3.1778 mL
20 mM 0.0953 mL 0.4767 mL 0.9533 mL 2.3833 mL
25 mM 0.0763 mL 0.3813 mL 0.7627 mL 1.9067 mL
30 mM 0.0636 mL 0.3178 mL 0.6356 mL 1.5889 mL
40 mM 0.0477 mL 0.2383 mL 0.4767 mL 1.1917 mL
50 mM 0.0381 mL 0.1907 mL 0.3813 mL 0.9533 mL
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Tuberculosis inhibitor 3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tuberculosis inhibitor 32219325-28-5Tuberculosis inhibitor3Tuberculosis inhibitor-3BacterialInhibitorinhibitorinhibit

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