Lys(CO-C3-p-I-Ph)-O-tBu
Based on 1 Customer Validation
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the pharmacokinetic properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound.
For research use only. We do not sell to patients.
- Purity: 98.14%
- CAS No.: 2703051-80-1
- Formula: C20H31IN2O3
- Molecular Weight:474.38
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Lys(CO-C3-p-I-Ph)-O-tBu can be used for construction of a PSMA molecule with improved biological and physical properties. PSMA is a 100 kD transmembrane enzyme and is mainly expressed in prostate tissue. PSMA can hydrolyze folic acid and increase intracellular glutamate levels. PSMA can be combined with targeted drugs (such as antibodies, small molecule ligands) to deliver drugs to prostate cancer cells. PSMA can be combined with radionuclides for PSMA targeted radionuclide therapy (TRT) and PSMA targeted imaging[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2703051-80-1
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Appearance Oil
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Molecular Weight 474.38
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Formula C20H31IN2O3
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Color Light yellow to yellow
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SMILES
IC1=CC=C(CCCC(NCCCC[C@@H](C(OC(C)(C)C)=O)N)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (210.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1080 mL | 10.5401 mL | 21.0801 mL | 52.7004 mL |
| 5 mM | 0.4216 mL | 2.1080 mL | 4.2160 mL | 10.5401 mL | |
| 10 mM | 0.2108 mL | 1.0540 mL | 2.1080 mL | 5.2700 mL | |
| 15 mM | 0.1405 mL | 0.7027 mL | 1.4053 mL | 3.5134 mL | |
| 20 mM | 0.1054 mL | 0.5270 mL | 1.0540 mL | 2.6350 mL | |
| 25 mM | 0.0843 mL | 0.4216 mL | 0.8432 mL | 2.1080 mL | |
| 30 mM | 0.0703 mL | 0.3513 mL | 0.7027 mL | 1.7567 mL | |
| 40 mM | 0.0527 mL | 0.2635 mL | 0.5270 mL | 1.3175 mL | |
| 50 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0540 mL | |
| 60 mM | 0.0351 mL | 0.1757 mL | 0.3513 mL | 0.8783 mL | |
| 80 mM | 0.0264 mL | 0.1318 mL | 0.2635 mL | 0.6588 mL | |
| 100 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5270 mL |
Lys(CO-C3-p-I-Ph)-O-tBu Related Classifications
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