EGFR-PK/JNK-2-IN-1
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2 with IC50s of 2.7 and 3.0 μM, respectively. EGFR-PK/JNK-2-IN-1 can induce apoptosis and induce cell cycle arrest at different cell phases. EGFR-PK/JNK-2-IN-1 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 3034838-06-4
- Formula: C22H17ClN4O3S
- Molecular Weight:452.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DLD-1 | IC50 |
29.8 μM
Compound: 6c
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Antiproliferative activity against human DLD-1 cells by WST-8 assay
Antiproliferative activity against human DLD-1 cells by WST-8 assay
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[PMID: 38408511] |
| K562 | IC50 |
15.4 μM
Compound: 6c
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Antiproliferative activity against human K562 cells by WST-8 assay
Antiproliferative activity against human K562 cells by WST-8 assay
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[PMID: 38408511] |
Chemical Information
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CAS No. 3034838-06-4
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Molecular Weight 452.91
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Formula C22H17ClN4O3S
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SMILES
ClC(C=C1)=CC=C1C2=CC(C(NC3=CC=C(S(=O)(N)=O)C=C3)=O)=NN2C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR-PK/JNK-2-IN-1 Related Classifications
HY-162332 Related Classifications
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