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ATV041 

Cat. No.: HY-152535
Handling Instructions

ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner.

For research use only. We do not sell to patients.

ATV041 Chemical Structure

ATV041 Chemical Structure

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Description

ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner[1].

IC50 & Target

Mouse hepatitis virus (MHV)[1]
In Vitro

ATV041 inhibits CCoV, FIPV and TGEV with EC50 values of 1.406 µM, 7.34 µM and 3.777 µM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

ATV041 (200 mg/kg; p.o.; single dose) is widely and rapidly distributes in plasma, liver, lung and kidney tissues[1].
ATV041 (10, 50 and 200 mg/kg; p.o.; single dose) inhibits virus replication in liver and lung in a dose-dependent manner. ATV041 down-regulates the expression of TNF-α、IL-1β、IL-6、IFN-γand CXCL10 inflammatory factors and improves tissue damage[1].
Pharmacokinetic (PK) parameters of GS-441524 and Ibuprofen in SD rats[1]
(GS-441524 and Ibuprofen are produced by hydrolysis of ATV041)

Analytes Route Dose (mg/kg) T1/2 (h) Tmax (h) Cmax (µM/L) AUC0-∞ (h•µM/L) MRT0-∞ (h) F (%)
GS-441524 p.o. 25.0 4.98±3.57 0.67±0.29 7.75±1.58 22.6±2.34 3.16±1.21 60.31±0.06
GS-441524 i.v. 5.0 2.81±3.28 0.08±0.00 5.67±0.57 7.51±0.85 1.28±0.139 -
Ibuprofen p.o. 25.0 2.63±1.78 0.67±0.29 80.2±12 263±37 3.35±0.925 78.42±0.11
Ibuprofen i.v. 5.0 1.58±0.82 0.03±0.00 41.8±3.12 67.1±4.39 1.57±0.294 -

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1].
Dosage: 5 or 25 mg/kg.
Administration: Oral gavage or intravenous injection; single dose.
Result: Showed an oral activity and efficacy.
Animal Model: BALB/c mice[1].
Dosage: 10, 50 and 200 mg/kg.
Administration: Oral gavage; single dose.
Result: Improved tissue distribution and reduced viral load, tissue damage, virus-induced inflammation.
Molecular Weight

479.53

Formula

C25H29N5O5
SMILES

O[[email protected]]1[[email protected]@H](O)[[email protected]](C#N)(C2=CC=C3C(N)=NC=NN32)O[[email protected]@H]1COC(C(C)C(C=C4)=CC=C4CC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

ATV041ATV 041ATV-041OthersBALB/c miceSD ratsIbuprofenGS-441524Antiviral agentAntiinflammatoryInhibitorinhibitorinhibit

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