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Homocarbonyltopsentin (Synonyms: PK4C9)

Cat. No.: HY-117389 Purity: 98.11%
Handling Instructions

Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM.

For research use only. We do not sell to patients.

Homocarbonyltopsentin Chemical Structure

Homocarbonyltopsentin Chemical Structure

CAS No. : 172286-77-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 179 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Homocarbonyltopsentin (PK4C9) is a small-molecule TSL2-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC50 value of 16 μM[1].

In Vitro

Homocarbonyltopsentin (PK4C9) (10-40 μM; 24 hours) shows an up to 5.2-fold decrease in the expression of E7-excluding SMN2 isoforms, and up to three-fold increase in E7-including isoforms in GM03813C cells[1].
Homocarbonyltopsentin (PK4C9) (40 μM; 24 hours) increased 1.5-fold SMN protein expression compared to GM03813C cells treated with DMSO[1].

RT-PCR[1]

Cell Line: GM03813C (SMA) cells; GM03814B fibroblasts cells
Concentration: 10-40 μM
Incubation Time: 24 hours
Result: E7 inclusion reached a maximum of 91% (25% increase, DMSO-treated cells).

Western Blot Analysis[1]

Cell Line: GM03813C (SMA) cells; GM03814B fibroblasts cells
Concentration: 40 μM
Incubation Time: 24 hours
Result: Increased SMN protein in SMA cells.
Molecular Weight

370.36

Formula

C₂₁H₁₄N₄O₃

CAS No.

172286-77-0

SMILES

O=C(C1=NC=C(C(C2=CNC3=C2C=CC=C3)=O)N1)C4=CNC5=C4C=CC(O)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (337.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7001 mL 13.5004 mL 27.0008 mL
5 mM 0.5400 mL 2.7001 mL 5.4002 mL
10 mM 0.2700 mL 1.3500 mL 2.7001 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.11%

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Keywords:

HomocarbonyltopsentinPK4C9OthersInhibitorinhibitorinhibit

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Homocarbonyltopsentin
Cat. No.:
HY-117389
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