PFKFB1 Protein, Human (HEK293, His)
Based on 1 Customer Validation
PFKFB1 protein orchestrates the synthesis and degradation of fructose 2,6-bisphosphate, regulating cellular energy metabolism. Serving as a key enzyme, PFKFB1 modulates fructose 2,6-bisphosphate levels, impacting glycolysis and gluconeogenesis. Its dual role in both synthesis and breakdown is crucial for maintaining cellular energy homeostasis, ensuring adaptability to changing energy demands and environmental conditions. PFKFB1 Protein, Human (HEK293, His) is the recombinant human-derived PFKFB1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
PFKFB1 protein orchestrates the synthesis and degradation of fructose 2,6-bisphosphate, regulating cellular energy metabolism. Serving as a key enzyme, PFKFB1 modulates fructose 2,6-bisphosphate levels, impacting glycolysis and gluconeogenesis. Its dual role in both synthesis and breakdown is crucial for maintaining cellular energy homeostasis, ensuring adaptability to changing energy demands and environmental conditions. PFKFB1 Protein, Human (HEK293, His) is the recombinant human-derived PFKFB1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
PFKFB1 protein takes center stage in the intricate orchestration of the synthesis and degradation of fructose 2,6-bisphosphate. As a key regulatory enzyme, PFKFB1 plays a crucial role in controlling cellular energy metabolism by modulating the levels of fructose 2,6-bisphosphate. This dual-function protein holds the responsibility of both synthesizing and breaking down fructose 2,6-bisphosphate, a pivotal metabolite that regulates glycolysis and gluconeogenesis. The dynamic interplay orchestrated by PFKFB1 is integral to maintaining the delicate balance of cellular energy homeostasis, influencing key metabolic pathways to ensure the cell's adaptability to varying energy demands and environmental conditions.
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
P16118 (S2-Y471)
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Molecular Construction
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N-term
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PFKFB1 (S2-Y471)
Accession # P16118 -
6*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
PFKFB1; 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 1 Splice Variant 2; Prev. PFRX; 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 1; 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase 1; 6PF-2-K/Fru-2,6-P2ASE Liver Isozyme; 6PF-2-K/Fru-2
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AA Sequence
SPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
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Predicted Molecular Mass
55.6 kDa
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Molecular Weight
Approximately 60 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5% Trehalose, 1 mM EDTA, pH 7.8 or 20mM PB, 150mM NaCl, 5%Trehalose, 1mM EDTA, 10% Glycerol, 0.1%Tween 80, pH7.8.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (238 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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