PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Also Known as F6PK; HL2K; PFRX

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5207

About PFKFB1

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:54,932,961-54,998,789 (from NCBI)

This gene has 4 transcripts (splice variants), 261 orthologues and 3 paralogues. Biased expression in fat (RPKM 14.1) and liver (RPKM 5.1).

Summary

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase Enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

PFKFB1 Products (3)

mRNA Protein Name
NM_001271804.2 NP_001258733.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271805.2 NP_001258734.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_002625.4 NP_002616.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

PFKFB1 Protein Structure

6PF2K

6PF2K: 6-phosphofructo-2-kinase (31 - 251)

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (254 - 400)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

  • 6PF-2-K/Fru-2,6-P2ASE liver isozyme

PFKFB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PFKFB1 P16118 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra
PFKFB1 P16118 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra
PFKFB1 P16118 PDE4A Homo sapiens P27815-4
Validated Y2H
32296183
Intra
PFKFB1 P16118 PDE4A Homo sapiens P27815-4
Y2H Array
32296183
Intra
PFKFB1 P16118 PDE4A Homo sapiens P27815-4
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 ZNF474 Homo sapiens Q6S9Z5
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 ZNF474 Homo sapiens Q6S9Z5
Validated Y2H
32296183
Intra
PFKFB1 P16118 ZNF474 Homo sapiens Q6S9Z5
Y2H Array
32296183
Intra
PFKFB1 P16118 ZNF688 Homo sapiens P0C7X2
Y2H Array
32296183
Intra
PFKFB1 P16118 ZNF688 Homo sapiens P0C7X2
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
PFKFB1 P16118 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
PFKFB1 P16118 PFKFB4 Homo sapiens Q16877
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PFKFB1 P16118 PFKFB4 Homo sapiens Q16877
Validated Y2H
32296183
Intra
PFKFB1 P16118 KATNBL1 Homo sapiens Q9H079
Validated Y2H
32296183
Intra
PFKFB1 P16118 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 PFKFB4 Homo sapiens Q16877
Y2H Array
32296183
Intra
PFKFB1 P16118 PFKFB1 Homo sapiens P16118
Validated Y2H
32296183
Intra
PFKFB1 P16118 PFKFB1 Homo sapiens P16118
Y2H Array
25416956
Intra
PFKFB1 P16118 GCK Homo sapiens P35557
ELISA
11522786
Intra
PFKFB1 P16118 PFKFB1 Homo sapiens P16118
X-Ray Diffraction
12379646
Intra
PFKFB1 P16118 KATNBL1 Homo sapiens Q9H079
Y2H Array
32296183
Intra
PFKFB1 P16118 PFKFB1 Homo sapiens P16118
Y2H Array
32296183
Intra
PFKFB1 P16118 KATNBL1 Homo sapiens Q9H079
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 PFKFB1 Homo sapiens P16118
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 DDIT4L Homo sapiens Q96D03
Validated Y2H
32296183
Intra
PFKFB1 P16118 ZNF276 Homo sapiens Q8N554
Y2H Array
32296183
Intra
PFKFB1 P16118 ZNF276 Homo sapiens Q8N554
Validated Y2H
32296183
Intra
PFKFB1 P16118 ZNF276 Homo sapiens Q8N554
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 PFKFB3 Homo sapiens Q16875
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 PFKFB3 Homo sapiens Q16875
Validated Y2H
32296183
Intra
PFKFB1 P16118 PFKFB3 Homo sapiens Q16875
Y2H Array
32296183
Intra
PFKFB1 P16118 PLEKHG4 Homo sapiens Q58EX7
Validated Y2H
32296183
Intra
PFKFB1 P16118 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
PFKFB1 P16118 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PFKFB1 Proteins

Cat. No. Product Name Accession Purity
HY-P71118 PFKFB1 Protein, Human (HEK293, His) P16118 (S2-Y471) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-178367 PFKFB4-IN-1 99.91% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-RS10361 PFKFB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20187 Pfkfb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26691 Pfkfb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PFKFB1 MGD MGI:107816
Rattus norvegicus PFKFB1 RGD RGD:3307
Felis catus PFKFB1 VGNC VGNC:68803
Bos taurus PFKFB1 VGNC VGNC:32769
Canis familiaris PFKFB1 VGNC VGNC:44442
Macaca mulatta PFKFB1 VGNC VGNC:75957
Others PFKFB1 NCBI