PFKFB1 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Gene

Homo sapiens

Also known as F6PK; HL2K; PFRX

Gene ID: 5207 | Gene type: protein coding

About PFKFB1

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:54,932,961-54,998,789 (from NCBI)

This gene has 4 transcripts (splice variants), 261 orthologues and 3 paralogues. Biased expression in fat (RPKM 14.1) and liver (RPKM 5.1).

Summary

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The Enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this Enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

PFKFB1 Products(3)

mRNA	Protein	Name
NM_001271804.2	NP_001258733.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 2
NM_001271805.2	NP_001258734.1	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 3
NM_002625.4	NP_002616.2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform 1

PFKFB1 Protein Structure

6PF2K

His_Phos_1

0
100
200
300
400
471 a.a.

Protein Preferred Names

Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

6PF-2-K/Fru-2,6-P2ASE liver isozyme

Recombinant PFKFB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71118	PFKFB1 Protein, Human (HEK293, His)	P16118 (S2-Y471)	≥95%

Related Diseases

Diseases

Alias

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101972	AZ-PFKFB3-67	Inhibitor	97.20%	Unkown
HY-101971	AZ PFKFB3 26	Inhibitor	99.23%	Unkown
HY-101972A	AZ-PFKFB3-67 quarterhydrate	Inhibitor	≥99.0%	Unkown
HY-RS10361	PFKFB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PFKFB1	MGD	MGI:107816
Rattus norvegicus	PFKFB1	RGD	RGD:3307
Felis catus	PFKFB1	VGNC	VGNC:68803
Bos taurus	PFKFB1	VGNC	VGNC:32769
Canis familiaris	PFKFB1	VGNC	VGNC:44442
Macaca mulatta	PFKFB1	VGNC	VGNC:75957
Others	PFKFB1	NCBI

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