2. Immunology/Inflammation
  3. IRAK
  4. IRAK4-IN-15

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. .

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IRAK4-IN-15 Chemical Structure

IRAK4-IN-15 Chemical Structure

CAS No. : 2667681-85-6

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IRAK4-IN-15 Related Antibodies

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Description

IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. [1].

IC50 & Target[1]

IRAK4

0.002 μM (IC50)

In Vitro

IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC50 of 0.21 µM[1].
IRAK4-IN-15 (compound 35) shows selectivity with IC50s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRAK4-IN-15 Related Antibodies
Molecular Weight

488.56

Formula

C25H29FN10
CAS No.
SMILES

CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IRAK4-IN-15 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRAK4-IN-152667681-85-6IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseAcalabrutinibintrinsic clearanceMyD88/CD79ABC-DLBCLCaco2 cellsInhibitorinhibitorinhibit

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