IRAK4-IN-15
IRAK4-IN-15 (compound 35) is a potent and selective IRAK4 inhibitor with an IC50 of 0.002 µM. IRAK4-IN-15 shows good human PK predictions with low intrinsic clearance. IRAK4-IN-15 shows great synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib. .
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- CAS No.: 2667681-85-6
- Formule: C25H29FN10
- Masse moléculaire:488.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IRAK4 0.002 μM (IC50) |
In Vitro
IRAK4-IN-15 (compound 35) shows cell pIRAK4 potencies with an IC50 of 0.21 µM[1].
IRAK4-IN-15 (compound 35) shows selectivity with IC50s of 0.002,1.2, >10,1.5, 0.23, 0.48, 0.93, 0.57 µM for IRAK4, IRAK1, BTK, Flt3, PI3Kδ, TRKa, TRKb, TRKc, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2667681-85-6
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Masse moléculaire 488.56
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Formule C25H29FN10
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SMILES
CC1=NC=C(C2=NC3=C(NC(C)C)N=C(NC4=CN(C(C5)CC65CN(C)C6)N=C4)N=C3C=C2F)C=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IRAK4-IN-15 Related Classifications
HY-146113 Related Classifications
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