1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. AMA-37

AMA-37 

Cat. No.: HY-100706
Handling Instructions

AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively.

For research use only. We do not sell to patients.

AMA-37 Chemical Structure

AMA-37 Chemical Structure

CAS No. : 404009-46-7

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Description

AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2].

IC50 & Target

IC50: 0.27 μM (DNA-PK)[1].

In Vitro

AMA-37 inhbits PI3K poorly[2].
AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3].
Inhibition of DNA-PK with AMA37 leads to radiosensitization[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

283.32

Formula

C₁₇H₁₇NO₃

CAS No.
SMILES

O=C(C1=CC=C(N2CCOCC2)C=C1O)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥99.0%

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Keywords:

AMA-37AMA37AMA 37DNA-PKDNA-dependent protein kinasep110MCF-7G0cellarrest,Inhibitorinhibitorinhibit

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