Anti-Mouse NK1.1 Antibody (PK136)
Based on 1 Customer Validation
Anti-Mouse NK1.1 Antibody (PK136) is an anti-mouse NK1.1 IgG2a monoclonal antibody. Anti-Mouse NK1.1 Antibody (PK136) can deplete natural killer (NK) cells. Anti-Mouse NK1.1 Antibody (PK136) inhibits the JAK-STAT and NF-κB signaling pathways. Anti-Mouse NK1.1 Antibody (PK136) can be used for research on inflammation conditions such as non-alcoholic steatohepatitis (NASH).
For research use only. We do not sell to patients.
- Purity: 98.57%
- Molecular Weight:150 kDa
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Mouse IgG2a kappa
Mouse
|
NF-κB |
p-STAT3 |
STAT1 |
Anti-Mouse NK1.1 Antibody (PK136) (150 μg, i.p., once every 3 days, from week 7 to week 11) can improve non-alcoholic steatohepatitis (NASH) in male C57BL/6 mice fed with methionine- andcholine-deficient (MCD) diet[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:5×105 Panc02 cells injected male C57BL/6 mice (6 weeks)[1]
-
Dosage:90 µg
-
Administration:/, on day 1 before tumor engraftment and on day 1, 4, 7, 14, 21 after Panc02 cells inoculation
-
Result:Significantly reduced the number of NK cells.
Significantly increased tumor weight.
-
Animal Model:Male C57BL/6 mice (6-8 weeks) fed with MCD diet (4 weeks)[2]
-
Dosage:150 μg
-
Administration:Intraperitoneal injection (i.p.), once every 3 days from week 7 to week 11
-
Result:Significantly reduced the number of NK cells.
Ruduced the level of p-STAT1, p-STAT3, and p-NF-κB p65.
Improved NASH inflammation in mice.
17057 [NCBI]
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Product Image
in vivo Cell Specific Depletion; Flow Cytometry
Chemical Information
-
Appearance Liquid
-
Molecular Weight 150 kDa
-
Color Colorless to light yellow
-
SMILES
[Anti-Mouse NK1.1 Antibody (PK136)]
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
-
Data Sheet (261 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Liang Y, et al. Upregulation of Lactobacillus spp. in gut microbiota as a novel mechanism for environmental eustress-induced anti-pancreatic cancer effects. Gut Microbes. 2025 Dec;17(1):2470372. [Content Brief]
[2]. Wang F, et al. Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway. Cell Mol Gastroenterol Hepatol. 2022;13(1):257-274. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse NK1.1 Antibody (PK136) Related Classifications
HY-P99143 Related Classifications
Powered by Bioz