Anti-Mouse CD8α Antibody (2.43)
Based on 1 Customer Validation
Anti-Mouse CD8α Antibody (2.43) is an anti-mouse CD8α IgG2b monoclonal antibody. Anti-Mouse CD8α Antibody (2.43) can significantly deplete CD8+ T cells. Anti-Mouse CD8α Antibody (2.43) can prolong the survival time of liver cell transplantation. Anti-Mouse CD8α Antibody (2.43) can be used for research on immunology. The recommend isotype control of Anti-Mouse CD8α Antibody (2.43): Rat IgG2b kappa, Isotype Control (HY-P990682).
For research use only. We do not sell to patients.
- Purity: 98.78%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rat IgG2b kappa
Mouse
CD8α
Anti-Mouse CD8α Antibody (2.43) (250 μg, i.p., on the 4th and 2nd day before transplantation) significantly prolongs the survival of liver cell transplants by effectively depleting CD8+ T cells in C57BL/6.SCID mice[2].
Anti-Mouse CD8α Antibody (2.43) (100 μg, i.p., on day -1, 0, 1, 7, 21 and 36) exhausts CD8+ T cells and enhances the severity of arthritis in female BALB/c mice with a Chondroitin sulfate (CS) (HY-B2162)-depleted human fetal aggrecan (HFPG) induced arthritis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice (7-8 weeks) bearing CT26 tumors[1]
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Dosage:300 μg
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Administration:Intraperitoneal injection (i.p.), once daily, for 3 days
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Result:Significantly reduced CD45+CD8a+ cells.
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Animal Model:C57BL/6.SCID mice (4-6 weeks)[2]
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Dosage:250 μg
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Administration:Intraperitoneal injection (i.p.), on the 4th and 2nd day before transplantation
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Result:Significantly reduced CD8+ T cells.
Extended the survival time of transplants.
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Animal Model:CS-depleted HFPG (75 μg) induced female BALB/c mice (6-8 months)[3]
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Dosage:100 μg
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Administration:Intraperitoneal injection (i.p.), on day -1, 0, 1, 7, 21 and 36
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Result:Caused earlier onset and significantly higher severity of arthritis.
Caused 3 mice to reach the highest score.
P01731-1
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
in vivo CD8+ T cell depletion; Western blot
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD8a Antibody (2.43)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Kristensen LK, et al. CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models. Theranostics. 2019 Oct 18;9(26):8221-8238. [Content Brief]
[2]. Bumgardner GL, et al. Rejection responses to allogeneic hepatocytes by reconstituted SCID mice, CD4, KO, and CD8 KO mice. Transplantation. 2000 Dec 27;70(12):1771-80. [Content Brief]
[3]. Banerjee S, et al. The induction of arthritis in mice by the cartilage proteoglycan aggrecan: roles of CD4+ and CD8+ T cells. Cell Immunol. 1992 Oct 15;144(2):347-57. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD8α Antibody (2.43) Related Classifications
HY-P990790 Related Classifications
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