Anti-Mouse CD20 Antibody (MB20-11)
Based on 1 publication(s) in Google Scholar
Anti-Mouse CD20 Antibody (MB20-11) is a kind of mouse IgG2c antibody inhibitor, targeting to CD20. Anti-Mouse CD20 Antibody (MB20-11) can deplete mature B cells in lymphoid tissues. Anti-Mouse CD20 Antibody (MB20-11) can be used for the researches of cancer, immunology and metabolic Disease, such as lymphoma and diabetes.
For research use only. We do not sell to patients.
- Purity : 98.79%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Anti-Mouse CD20 Antibody (MB20-11)
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Biological Activity
Description
Isotype
Mouse IgG2c kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
CD20
In Vivo
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, a single dose) depletes more than 95% of mature B cells in lymphoid tissues with the effect lasting up to 8 weeks in WT mice[2].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, a single dose) suppresses tumor growth in BL3750 tumor mice models[2].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, i.v., 3 times at 2-wk intervals) depletes 90% of blood and 70% of spleen B cells in non-obese diabetic mice[3].
Anti-Mouse CD20 Antibody (MB20-11) (250 μg, i.v., 3 times at 2-wk intervals) prevents or delays the progression of type 1 diabetes in non-obese diabetic mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BL3750 tumor mice models[1]
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Dosage:250 μg
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Administration:Intravenously injection
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Result:Increased survival rate of mice.
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Animal Model:BL3750 tumor mice models[2]
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Dosage:250 μg
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Administration:/
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Result:Suppressed tumor growth, with 89% of mice remaining disease free for 60 days or longer.
Reduced peritoneal B2 cell numbers.
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Animal Model:Non-obese diabetic mice models[3]
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Dosage:250 μg
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Administration:Intravenously injection, 3 times at 2-wk intervals
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Result:Reduced circulating B cell numbers remained by 95%.
The majority of NOD mice remained diabetes free for up to 53 weeks.
Reduced the frequency of intrainsulitis and lymphocytes.
Significantly delayed diabetes onset when treated three times with CD20 mAb (weeks 15, 17, 19).
Reduces T cell proliferation.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo B cell depletion; Western blot
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD20 Antibody (MB20-11)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Immunother Cancer
Tumor-derived HMGB2 induces M2-like macrophage polarization via TRIM65-mediated NLRP3 degradation to promote DLBCL progression. [Abstract]2026 Jun 10;14(6):e015018. PMID: 42270158
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Minard-Colin V, et al. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood. 2008 Aug 15;112(4):1205-13. [Content Brief]
[2]. Horikawa M, et al. Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest. 2011 Nov;121(11):4268-80. [Content Brief]
[3]. Xiu Y, et al. B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. J Immunol. 2008 Mar 1;180(5):2863-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD20 Antibody (MB20-11) Related Classifications
HY-P990806 Related Classifications
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