7-Ketositosterol

Cat. No.: HY-N2757 Purity: 99.9%: Data Sheet
COA

SDS
Handling Instructions
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7-Ketositosterol is a phytosterol isolated from the fruits of the mulberry tree (Morus alba L.). 7-Ketositosterol can significantly inhibit Cisplatin (HY-17394)-induced apoptosis in LLC-PK1 cells and has the potential to improve Cisplatin-induced nephrotoxicity.

For research use only. We do not sell to patients.

7-Ketositosterol Chemical Structure

CAS No. : 2034-74-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 μg/mL Compound: 8	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 23511021]
BV-2	IC₅₀	> 100 μM Compound: 36	Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay	[PMID: 28911817]
HT-29	IC₅₀	48 μM Compound: 29	Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay	[PMID: 20931970]
Hep 3B2	IC₅₀	> 20 μg/mL Compound: 8	Cytotoxicity against human Hep3B cells Cytotoxicity against human Hep3B cells	[PMID: 23511021]
HepG2	IC₅₀	> 20 μg/mL Compound: 8	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 23511021]
MCF7	IC₅₀	> 20 μg/mL Compound: 8	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 23511021]
MDA-MB-231	IC₅₀	> 20 μg/mL Compound: 8	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 23511021]

Molecular Weight

428.69

Formula

C₂₉H₄₈O₂

CAS No.

2034-74-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3=O)C

Structure Classification

Steroids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : 12 mg/mL (27.99 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3327 mL	11.6634 mL	23.3269 mL
5 mM	0.4665 mL	2.3327 mL	4.6654 mL
10 mM	0.2333 mL	1.1663 mL	2.3327 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.9%

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Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (527 KB) RP-HPLC (277 KB) MS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Lee D, et al. Identification of Renoprotective Phytosterols from Mulberry (Morus alba) Fruit against Cisplatin-Induced Cytotoxicity in LLC-PK1 Kidney Cells. Plants (Basel). 2021 Nov 17;10(11):2481. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	2.3327 mL	11.6634 mL	23.3269 mL	58.3172 mL
	5 mM	0.4665 mL	2.3327 mL	4.6654 mL	11.6634 mL
	10 mM	0.2333 mL	1.1663 mL	2.3327 mL	5.8317 mL
	15 mM	0.1555 mL	0.7776 mL	1.5551 mL	3.8878 mL
	20 mM	0.1166 mL	0.5832 mL	1.1663 mL	2.9159 mL
	25 mM	0.0933 mL	0.4665 mL	0.9331 mL	2.3327 mL