Ac-PSMA-trillium 

Ac-PSMA-trillium is a PSMA targeting compound, consisting of a PSMA targeting molecule (PSMA binder), a Macropa chelating molecule, and a group that regulates pharmacokinetics (PK modifier). Ac-PSMA-trillium is a non-radioactive form of Actinium-225-PSMA-Trillium (BAY 3563254) with improved PSMA targeting and pharmacokinetic properties. PSMA-trillium can bind Ac through the Macropa chelating molecule, or the radioactive isotope ²²⁵Actinium. Actinium-225-PSMA-Trillium is a potent inhibitor of metastatic castration-resistant prostate cancer (mCRPC)^[1][2].

2612.46

C₁₀₇H₁₅₈AcIN₁₇O₃₄S⁺

O=C(O)[C@H](CCC(O)=O)NC(N[C@@H](CCCCNC(NC1=CC(C2=CN(CCOCCOCCOCCC(N[C@@H](CCCCNC(NC3=CC=C(CCOC4=CC5=[N]C(C[N@@]67[Ac+3]([O](CC8)CC9)([O](CC%10)CC%11)([O]%10CC6)([O]8CC7)([O-]C%12=O)([O-]C5=O)[N@]9%11CC%13=CC=CC%12=[N]%13)=C4)C=C3)=S)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(N[C@H](C(O)=O)CCCCNC(CCCC%14=CC=C(I)C=C%14)=O)=O)=O)=O)N=N2)=CC=C1)=O)C(O)=O)=O.C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zitzmann-Kolbe S, et al., Preclinical evaluation of an actinium-225 labeled PSMA-targeting small molecule (225Ac-PSMA-Trillium (BAY 3563254)) for the treatment of metastatic castration resistant prostate cancer (mCRPC)[J]. Cancer Research, 2024, 84(6_Supplement): 6033-6033.