Lys(CO-C3-p-I-Ph)-OMe
Based on 1 Customer Validation
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC).
For research use only. We do not sell to patients.
- Purity: 97.19%
- CAS No.: 2088426-96-2
- Formula: C17H25IN2O3
- Molecular Weight:432.30
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2088426-96-2
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Appearance Solid
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Molecular Weight 432.30
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Formula C17H25IN2O3
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Color White to off-white
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SMILES
IC1=CC=C(CCCC(NCCCC[C@@H](C(OC)=O)N)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (115.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3132 mL | 11.5660 mL | 23.1321 mL | 57.8302 mL |
| 5 mM | 0.4626 mL | 2.3132 mL | 4.6264 mL | 11.5660 mL | |
| 10 mM | 0.2313 mL | 1.1566 mL | 2.3132 mL | 5.7830 mL | |
| 15 mM | 0.1542 mL | 0.7711 mL | 1.5421 mL | 3.8553 mL | |
| 20 mM | 0.1157 mL | 0.5783 mL | 1.1566 mL | 2.8915 mL | |
| 25 mM | 0.0925 mL | 0.4626 mL | 0.9253 mL | 2.3132 mL | |
| 30 mM | 0.0771 mL | 0.3855 mL | 0.7711 mL | 1.9277 mL | |
| 40 mM | 0.0578 mL | 0.2892 mL | 0.5783 mL | 1.4458 mL | |
| 50 mM | 0.0463 mL | 0.2313 mL | 0.4626 mL | 1.1566 mL | |
| 60 mM | 0.0386 mL | 0.1928 mL | 0.3855 mL | 0.9638 mL | |
| 80 mM | 0.0289 mL | 0.1446 mL | 0.2892 mL | 0.7229 mL | |
| 100 mM | 0.0231 mL | 0.1157 mL | 0.2313 mL | 0.5783 mL |
Lys(CO-C3-p-I-Ph)-OMe Related Classifications
HY-158118 Related Classifications
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