1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. ATM/ATR
    DNA-PK
    PI3K
  3. ATR-IN-15

ATR-IN-15 

Cat. No.: HY-147567
Handling Instructions

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively.

For research use only. We do not sell to patients.

ATR-IN-15 Chemical Structure

ATR-IN-15 Chemical Structure

CAS No. : 2756665-52-6

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Description

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].

IC50 & Target

ATR

8 nM (IC50)

PI3K

5131 nM (IC50)

ATM

> 10000 nM (IC50)

Molecular Weight

378.43

Formula

C19H22N8O

CAS No.
SMILES

CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[[email protected]](C)COCC4)C5=CC=NN5C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ATR-IN-15
Cat. No.:
HY-147567
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