2756665-52-6
2756665-52-6
Chemical Structure
ATR-IN-15
- CAS No.: 2756665-52-6
- Formula:C19H22N8O
- Molecular Weight:378.43
IUPAC Name: (R)-3-methyl-4-(6-methyl-2-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)imidazo[1,5-a]pyrimidin-4-yl)morpholine
InChIKey: ZZBXMUWXLWRZGV-GFCCVEGCSA-N
SMILES: CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[C@H](C)COCC4)C5=CC=NN5C
Biological Activity: ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].
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ATR-IN-15 | ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively. | |||||||||||||||||||||
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References
Keywords
