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Protein kinase affinity probe 1 

Cat. No.: HY-136219
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Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3).

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Protein kinase affinity probe 1 Chemical Structure

Protein kinase affinity probe 1 Chemical Structure

CAS No. : 2098621-90-8

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Description

Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs). Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3)[1].

In Vitro

“S” indicates that the PKI (Purvalanol B) is sepharose-bound[1].
In a series of pull-down experiments from the lysates of HeLa cells, the effects of 0.1, 0.5, 1, 2, 5, 10, 25, and 50% loadings of PK inhibitors is determined. Examine higher bead loadings (75 and 100%) are prevented due to lack of compound solubility and poor reproducibility of the synthesis outcomes. 50% loading is the highest feasible in this study[1].

Molecular Weight

531.09

Formula

C₂₆H₃₉ClN₈O₂

CAS No.

2098621-90-8

SMILES

O=C(NCCCCCCN)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[[email protected]@H](CO)C(C)C)=N2)C=C1Cl

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Protein kinase affinity probe 1Protein kinase affinity probe1Protein kinase affinity probe-1OthersprobePKIPKsepharoseaffinityHeLaInhibitorinhibitorinhibit

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Protein kinase affinity probe 1
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HY-136219
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